{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:17:02Z","timestamp":1793931422408,"version":"4.8.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100016387","name":"Grifols","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016387","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>The efficacy and safety of fostamatinib in adult patients with persistent\/chronic immune thrombocytopenia (p\/c ITP) were demonstrated in the FIT\u20101\/FIT\u20102 trials. This retrospective, multicentre observational study evaluated real\u2010world outcomes in consecutive p\/c ITP patients treated with fostamatinib in Italy. The primary end\u2010point, serving as a surrogate for both efficacy and safety, was the proportion of patients receiving fostamatinib for at least 6\u2009months. Ninety\u2010five patients were enrolled across 20 Italian centres, 59% female, median age 64\u2009years (range 21\u201386). The median time from ITP diagnosis to fostamatinib initiation was 7.7\u2009years; the median number of prior therapies was 4, including 54% of patients who received more than one thrombopoietin receptor agonist (TPO\u2010RA) and 23% who underwent splenectomy. The overall response rate was 73%, with 32% complete responses. Most patients (74%) achieved a response within the first month. Concerning the primary end\u2010point, 45% of patients received fostamatinib for 6\u2009months; the median treatment duration was 7.3\u2009months. The main cause of discontinuation was treatment failure (43%). Fifty\u2010nine adverse events were reported in 38 patients, mostly grade 1\u20132, leading to fostamatinib discontinuation in 8% of patients. This real\u2010world data confirm fostamatinib as an effective and safe option in relapsed\/refractory ITP.<\/jats:p>","DOI":"10.1111\/bjh.70069","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T06:45:22Z","timestamp":1756190722000},"page":"2529-2538","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Real\u2010world efficacy and safety of fostamatinib in\n                    <scp>ITP<\/scp>\n                    patients: Italian multicentre experience.\n                    <scp>GIMEMA ITP1122<\/scp>\n                    study"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4857-8325","authenticated-orcid":false,"given":"Elisa","family":"Lucchini","sequence":"first","affiliation":[{"name":"UCO Ematologia Azienda Sanitaria Universitaria Giuliano\u2010Isontina  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Vianelli","sequence":"additional","affiliation":[{"name":"Hematology Institute \u2018Lorenzo &amp; Ariosto Ser\u00e0gnoli\u2019 IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna, Policlinico S. Orsola  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugo","family":"Consoli","sequence":"additional","affiliation":[{"name":"UOC Ematologia ARNAS Garibaldi  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Carli","sequence":"additional","affiliation":[{"name":"Hematology Unit Ospedale San Bortolo, ULSS8 Berica  Vicenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Carrai","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero Universitaria Careggi SOD Ematologia  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4355-3954","authenticated-orcid":false,"given":"Monica","family":"Carpenedo","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Molecular Medicine, Niguarda Cancer Center ASST Grande Ospedale Metropolitano Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5178-5827","authenticated-orcid":false,"given":"Valerio","family":"De Stefano","sequence":"additional","affiliation":[{"name":"Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche Universit\u00e0 Cattolica, Policlinico \u2018A. 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