{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:28:05Z","timestamp":1760142485897,"version":"build-2065373602"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","award":["A2022349"],"award-info":[{"award-number":["A2022349"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2018A030313524"],"award-info":[{"award-number":["2018A030313524"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This research aimed to elucidate the association of Homeo Box\u00a011 (<jats:italic>HOX11<\/jats:italic>) gene overexpression with refractory acute B\u2010cell lymphoblastic leukaemia (B\u2010ALL). In this investigation, 209 patients with B\u2010ALL, who were treated in Guangdong Province between 2019 and 2024, were included. At the initial diagnosis, the RNA was obtained from bone marrow for genetic testing via Real\u2010time Quantitative Polymerase Chain Reaction (RQ\u2010PCR). Furthermore, the clinical data were acquired and the association of <jats:italic>HOX11<\/jats:italic> with these clinical features and gene alterations was analysed. Finally, the relationship between gene alterations and progression\u2010free survival (PFS) was analysed. Of the 209 B\u2010ALL patients, 42 (20.1%) had recurrent disease. Twenty\u2010six (12.4%) had <jats:italic>HOX11<\/jats:italic> overexpression, of which 10 had recurrent disease. Furthermore, the <jats:italic>HOX11<\/jats:italic> overexpression patients indicated <jats:italic>TP53<\/jats:italic> concomitant of 23.07%, whereas the <jats:italic>HOX11<\/jats:italic> low\u2010expression patients showed <jats:italic>TP53<\/jats:italic> concomitant of 8.7% (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Logistic regression indicated lower WBC counts and higher recurrence rates in the <jats:italic>HOX11<\/jats:italic> overexpression group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). PFS analysis indicated that the <jats:italic>HOX11<\/jats:italic> overexpression group and <jats:italic>KMT2A::AFF1<\/jats:italic> group were associated with higher disease recurrence (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Cox regression analysis showed that <jats:italic>HOX11<\/jats:italic> was an independent risk factor affecting PFS (<jats:italic>p<\/jats:italic>\u2009=\u20090.041). These findings are the first to demonstrate an association between <jats:italic>HOX11<\/jats:italic> overexpression and recurrent B\u2010ALL.<\/jats:p>","DOI":"10.1111\/bjh.70071","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T09:44:57Z","timestamp":1754387097000},"page":"1301-1308","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp><i>HOX11<\/i><\/scp> gene overexpression is associated with recurrence of acute B lymphoblastic leukaemia"],"prefix":"10.1111","volume":"207","author":[{"given":"Mingyan","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Paediatric Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Southern Medical University  Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changxin","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nanfang Hospital Southern Medical University  Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8721-0876","authenticated-orcid":false,"given":"Yulian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Southern Medical University  Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingji","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Southern Medical University  Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Paediatric Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Southern Medical University  Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bei","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Paediatric Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Southern Medical University  Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nanfang Hospital Southern Medical University  Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7734-2226","authenticated-orcid":false,"given":"Jinfang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Paediatric Hematology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Southern Medical University  Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,5]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-024-00525-x"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-023-00853-3"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.8018"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2019.04.003"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052603"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-018-0136-6"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023021501"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-08-832105"},{"issue":"11","key":"e_1_2_14_10_1","article-title":"The role of NKL Homeobox genes in T\u2010cell malignancies","volume":"9","author":"Nagel S","year":"2021","journal-title":"Biomedicine"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.20.8900"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.330"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-04-079988"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.797194"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2025.01.003"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-024-02474-6"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15542-6"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13008-024-00131-z"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.1943986"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noq074"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2003.09.001"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(19)30003-1"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020001466"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.34.8144"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-704973"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.176"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-024-02264-0"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402892"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-10378-w"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.2514"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-9-181"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.02.013"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2018.07.007"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T10:10:18Z","timestamp":1760091018000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.70071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,5]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/bjh.70071"],"URL":"https:\/\/doi.org\/10.1111\/bjh.70071","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"type":"print","value":"0007-1048"},{"type":"electronic","value":"1365-2141"}],"subject":[],"published":{"date-parts":[[2025,8,5]]},"assertion":[{"value":"2025-01-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}