{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:29:31Z","timestamp":1783020571233,"version":"3.54.6"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Hydroxyurea (hydroxycarbamide; HU) has been shown to be a safe and effective drug for individuals living with sickle cell disease (SCD) in Africa. However, reports of large\u2010scale use of HU outside of controlled trial settings are limited on the continent. Access to HU in Ghana has improved through a major public\u2013private partnership aimed at enhancing holistic care for communities affected by SCD. We evaluated the effectiveness of this programme through the measurement of biomarkers identified from health records, changes in clinical outcomes and quality of life (QoL) reported through interviews with participants and\/or caregivers. The haemoglobin (Hb) levels of participants enrolled in the programme between September 2019 and July 2023 (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091549) increased on average by 0.55\u2009g\/dL (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), with 9.2% of participants achieving Hb \u226510\u2009g\/dL. Six hundred participants and caregivers interviewed from April to November 2023 reported a significant reduction in the number of pain crises, malarial episodes, incidence of blood transfusions and rate of hospitalisations. Adults and children with SCD reported improved QoL in areas of physical, emotional, social and school\u2010related functioning. Lessons learned are expected to inform future efforts in Ghana and may support HU access programmes in other countries where SCD is highly endemic.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70079","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T05:33:33Z","timestamp":1754631213000},"page":"2099-2108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness of hydroxyurea (hydroxycarbamide) in a national sickle cell disease programme in Ghana"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2726-9929","authenticated-orcid":false,"given":"Duah","family":"Dwomoh","sequence":"first","affiliation":[{"name":"Department of Biostatistics University of Ghana School of Public Health, College of Health Sciences, University of Ghana  Accra Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Nana Yaw","family":"Abankwah","sequence":"additional","affiliation":[{"name":"Department of Health Policy Planning and Management University of Ghana School of Public Health, College of Health Sciences, University of Ghana  Accra Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amma A.","family":"Benneh\u2010Akwasi Kuma","sequence":"additional","affiliation":[{"name":"Department of Haematology University of Ghana Medical School, College of Health Sciences, University of Ghana  Accra Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Quartey","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy University of Ghana School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana  Accra Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwaku","family":"Marfo","sequence":"additional","affiliation":[{"name":"IQVIA Research and Development Solutions  Accra Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Spector","sequence":"additional","affiliation":[{"name":"Novartis Institutes for BioMedical Research, Inc.  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etta Forson","family":"Addo","sequence":"additional","affiliation":[{"name":"Sickle Cell Foundation of Ghana  Accra Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olufolake","family":"Egbujo","sequence":"additional","affiliation":[{"name":"Novartis Pharmaceutical Corporation  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomon Fiifi","family":"Ofori\u2010Acquah","sequence":"additional","affiliation":[{"name":"Sickle Cell Foundation of Ghana  Accra Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwaku","family":"Ohene\u2010Frempong","sequence":"additional","affiliation":[{"name":"Sickle Cell Foundation of Ghana  Accra Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justice","family":"Nonvignon","sequence":"additional","affiliation":[{"name":"Department of Health Policy Planning and Management University of Ghana School of Public Health, College of Health Sciences, University of Ghana  Accra Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(23)00118-7"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(21)00191-5"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30293-2"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.5334\/aogh.4132"},{"key":"e_1_2_13_6_1","unstructured":"MOH and Novartis sign MOU on treatment of Sickle Cell Disease at World Economic Forum 2019; 2019."},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.HS9.0000821484.39112.40"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(24)00078-4"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1813598"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2023.06.001"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h1258"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.89.9.1322"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1961.01710120031004"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24587"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.10.2555.2555"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1006\/bcmd.2000.0328"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.5581\/1516-8484.20120107"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2000146"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2007.09.013"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3182114c54"},{"key":"e_1_2_13_22_1","unstructured":"YeboahRM.NHIS now covers childhood cancers sickle cell treatment \u2013 Bawumia announces. Modern Ghana; 2022."}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70079","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.70079","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:08:35Z","timestamp":1783015715000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.70079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,7]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/bjh.70079"],"URL":"https:\/\/doi.org\/10.1111\/bjh.70079","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,7]]},"assertion":[{"value":"2025-04-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}