{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:30:36Z","timestamp":1788395436691,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970140"],"award-info":[{"award-number":["81970140"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370161"],"award-info":[{"award-number":["82370161"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We studied 60 chronic myeloid leukaemia (CML) patients with a prior history of accelerated phase (AP) including de novo AP (<jats:italic>n<\/jats:italic>\u2009=\u200919) and transformation to AP (<jats:italic>n<\/jats:italic>\u2009=\u20094), or tyrosine kinase inhibitor (TKI) therapy failure in the chronic phase (CP, <jats:italic>n<\/jats:italic>\u2009=\u200937), who discontinued TKI therapy. Median interval from diagnosis with AP or TKI therapy failure to achieving a deep molecular response (DMR) was 19\u2009months (interquartile range [IQR], 9\u201330\u2009months). Median TKI treatment and DMR duration were 108\u2009months (IQR, 72\u2013137\u2009months) and 59\u2009months (IQR, 39\u201387\u2009months) respectively. At a median follow\u2010up of 21\u2009months (IQR, 11\u201336\u2009months) after TKI discontinuation, 19 (31%) patients lost the major molecular response (MMR). The 3\u2010year probability of a sustained MMR was 59% (95% confidence interval [CI], [45%, 78%]). In the multivariable analyses, age at discontinuation &lt;32\u2009years (hazard ratio [HR]\u2009=\u20094.1 [1.3, 12.7], <jats:italic>p<\/jats:italic>\u2009=\u20090.014) and <jats:italic>BCR::ABL1<\/jats:italic> &gt;0.1% at 12\u2009months on TKI therapy (reference, \u22640.1%; HR\u2009=\u20093.9 [1.4, 11.5], <jats:italic>p<\/jats:italic>\u2009=\u20090.011) were significantly associated with a higher probability of MMR loss after TKI discontinuation. CML patients with a history of AP or TKI therapy failure may achieve successful treatment\u2010free remission after an adequate TKI therapy duration and a sustained DMR.<\/jats:p>","DOI":"10.1111\/bjh.70080","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T07:01:37Z","timestamp":1755068497000},"page":"1408-1415","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Treatment\u2010free remission in chronic myeloid leukaemia patients with accelerated phase or tyrosine kinase inhibitor therapy failure"],"prefix":"10.1111","volume":"207","author":[{"given":"Mengyao","family":"Yuan","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory of Cell and Gene Therapy for Haematologic Malignancies, National Clinical Research Center for Haematologic Disease, Peking University People's Hospital, Peking University Institute of Haematology Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Haematology, Henan Cancer Hospital The Affiliated Cancer Hospital of Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingcheng","family":"Liu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Blood Diseases, Institute of Haematology &amp; Blood Diseases Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Tianjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Shanghai Institute of Haematology Ruijin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6928-4027","authenticated-orcid":false,"given":"Yu","family":"Zhu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Haematology China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaolei","family":"Zang","sequence":"additional","affiliation":[{"name":"Department of Haematology, Qilu Hospital Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenfang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Haematopathology The First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi 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