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This population\u2010based study reports the incidence of SCNSL, risk factors and survival. All patients diagnosed with MCL in Denmark in 2010\u20132022 without confirmed CNS involvement at diagnosis were included. Data were retrieved from the Danish National Lymphoma Registry and medical records. In total, 873 patients (median age 70\u2009years) were included. The 10\u2010year cumulative incidence of SCNSL was 3.8% (95% confidence interval [CI] 2.4\u20135.2). Risk factors for SCNSL were blastoid\/pleomorphic MCL (hazard ratio [HR] 3.55, 95% CI 2.05\u20136.14), Ki67 \u226530% (HR 5.47, 95% CI 1.86\u201316.10) and elevated lactatedehydrogenase (HR 4.35, 95% CI 1.91\u20139.91). The 5\u2010year cumulative incidence of SCNSL for patients with blastoid\/pleomorphic MCL was 9.9% (95% CI 4.0\u201315.7). Patients with high CNS international prognostic index (CNS\u2010IPI) had a high 1\u2010year incidence of SCNSL of 5.8% (95% CI 1.6\u201310.0). Median progression\u2010free survival and overall survival were 1.8\u2009months (95% CI 1.3\u20134.7) and 2.4\u2009months (95% CI 1.3\u20138.9). In conclusion, SCNSL of MCL is rare and associated with poor survival. Blastoid\/pleomorphic subtype and high CNS\u2010IPI identified patients at high risk of SCNSL for whom upfront screening for CNS involvement should be considered.<\/jats:p>","DOI":"10.1111\/bjh.70082","type":"journal-article","created":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T06:20:10Z","timestamp":1754720410000},"page":"1366-1376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Secondary central nervous system lymphoma (<scp>SCNSL<\/scp>) in mantle cell lymphoma (<scp>MCL<\/scp>): Characteristics and risk factors in a Danish nationwide population\u2010based study"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4499-3126","authenticated-orcid":false,"given":"Trine","family":"Trab","sequence":"first","affiliation":[{"name":"Department of Hematology Rigshospitalet  Copenhagen Denmark"},{"name":"Biotech Research and Innovation Center (BRIC), University of Copenhagen  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