{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:19:12Z","timestamp":1784297952250,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:italic>NUP98<\/jats:italic>\u2010rearranged paediatric acute myeloid leukaemia (<jats:italic>NUP98<\/jats:italic>\u2010r pAML) has an extremely poor prognosis, and the impact of clinical parameters and therapeutic schemes on its outcomes remains unclear. We conducted a retrospective study of the largest pAML cohort (1779 patients) and found that <jats:italic>NUP98<\/jats:italic>\u2010r pAML has the worst prognosis among all subtypes. Furthermore, we identified white blood cell (WBC) count as the sole predictor of overall survival (OS) in <jats:italic>NUP98<\/jats:italic>\u2010r pAML patients and validated its adverse prognostic impact in both external paediatric and adult cohorts. <jats:italic>NUP98<\/jats:italic>\u2010r pAML patients were categorized into low\u2010risk (WBC count \u2264150\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L) and high\u2010risk (WBC count &gt;150\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L) groups based on WBC levels. Haematopoietic stem cell transplantation (HSCT) significantly improved OS and reduced the cumulative incidence of relapse (CIR) in the high\u2010risk group but not in the low\u2010risk group. Bortezomib significantly increased OS in <jats:italic>NUP98::NSD1<\/jats:italic> patients within the low\u2010risk group, and the combination of bortezomib and HSCT significantly enhanced OS in the entire <jats:italic>NUP98<\/jats:italic>\u2010r pAML cohort. CD33 antibody (Gemtuzumab ozogamicin, GO) is not recommended for the entire <jats:italic>NUP98<\/jats:italic>\u2010r pAML patients. In summary, WBC count is a pivotal marker for risk stratification and treatment decision\u2010making in <jats:italic>NUP98<\/jats:italic>\u2010r pAML patients.<\/jats:p>","DOI":"10.1111\/bjh.70096","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T06:16:48Z","timestamp":1755238608000},"page":"1464-1475","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["White blood cell count as a powerful prognostic marker and treatment guide in paediatric acute myeloid leukaemia with <scp><i>NUP98<\/i><\/scp> rearrangement"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3596-8826","authenticated-orcid":false,"given":"Hui","family":"Shi","sequence":"first","affiliation":[{"name":"Precision Oncology and Intelligent Theranostics Laboratory, Department of Pediatric Hematology and Oncology, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory 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University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Basic Medicine, School of Medicine Foshan University  Foshan Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Xun","sequence":"additional","affiliation":[{"name":"Department of Basic Medicine, School of Medicine Foshan University  Foshan Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Tomas","family":"Baptista\u2010Hon","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Macau University of Science and Technology  Macau SAR China"},{"name":"School of Medicine, University of Dundee  Dundee UK"},{"name":"Macau Institute for Artificial Intelligence in Medicine, Macau University of Science and Technology  Macau SAR 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