{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:14:08Z","timestamp":1793315648432,"version":"4.5.0"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    T\u2010cell lymphoblastic lymphoma (T\u2010LBL) is an aggressive lymphoma that primarily affects children and young adults, and a comprehensive understanding of its molecular features is crucial for improving patient outcomes. In this study, 552 patients were included, with targeted next\u2010generation sequencing of 262 lymphoma\u2010associated genes performed on tumour samples from 119 patients. The associations between mutations and survival rates, as well as relapse and other clinical factors, were analysed. The results demonstrated that pleural effusion (PE) invasion was significantly associated with adverse event\u2010free survival (EFS) and overall survival (OS) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Additionally, we identified 92 genes with recurrent mutations, among which\n                    <jats:italic>NOTCH1<\/jats:italic>\n                    (44%),\n                    <jats:italic>FBXW7<\/jats:italic>\n                    (28%),\n                    <jats:italic>PHF6<\/jats:italic>\n                    (11%),\n                    <jats:italic>KRAS<\/jats:italic>\n                    (10%) and\n                    <jats:italic>NRAS<\/jats:italic>\n                    (10%) were the most frequently altered. Patients with\n                    <jats:italic>NOTCH1<\/jats:italic>\n                    mutations exhibited improved EFS and OS (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01), whereas those carrying\n                    <jats:italic>CREBBP<\/jats:italic>\n                    ,\n                    <jats:italic>PTEN<\/jats:italic>\n                    and\n                    <jats:italic>LYST<\/jats:italic>\n                    mutations exhibited worse prognosis (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). In conclusion,\n                    <jats:italic>NOTCH1<\/jats:italic>\n                    mutations are associated with a favourable prognosis in paediatric T\u2010LBL, while\n                    <jats:italic>CREBBP<\/jats:italic>\n                    ,\n                    <jats:italic>PTEN<\/jats:italic>\n                    and\n                    <jats:italic>LYST<\/jats:italic>\n                    mutations, as well as PE invasion, are linked to poor prognosis. This study identifies key molecular and clinical factors in paediatric T\u2010LBL progression, aiding high\u2010risk patient identification and personalized treatment strategies.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70097","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T06:50:42Z","timestamp":1758091842000},"page":"1994-2005","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical features, mutational landscape and their prognostic impact in Chinese paediatric patients with T\u2010cell lymphoblastic lymphoma"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3695-6057","authenticated-orcid":false,"given":"Yang","family":"Li","sequence":"first","affiliation":[{"name":"Molecular Diagnostics Laboratory Beijing Gobroad Boren Hospital  Beijing 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Hebei Medical University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mincui","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Hematology Hunan Children's Hospital  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhong","family":"Xu","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Children's Hospital  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematologic Oncology Xi'an Children's Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Affiliated Hospital of Qingdao University  Qingdao 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