{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:47:37Z","timestamp":1788407257202,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The graft\u2010versus\u2010leukaemia effect (GVL) is closely associated with graft\u2010versus\u2010host disease (GVHD) after human leucocyte antigen (HLA)\u2010matched allogeneic stem\u2010cell transplantation (SCT) in acute lymphoblastic leukaemia (ALL). However, there are no data on this association following haploidentical SCT (haploSCT) with post\u2010transplant cyclophosphamide (PTCy). We assessed the impact of acute and chronic GVHD on haploSCT outcomes in 516 adult ALL patients. The cumulative incidence of acute GVHD grade II\u2013IV and III\u2013IV, chronic GVHD and extensive chronic GVHD was 33.3%, 11.7%, 35.3% and 11.8% respectively. The 2\u2010year relapse incidence (RI), non\u2010relapse mortality (NRM) and overall survival (OS) were 27.1%, 17.3% and 64.4% respectively. The time\u2010dependent hazard ratios (HRs) of acute GVHD grade II, grade III\u2013IV, limited and extensive chronic GVHD associated with RI were 0.92 (95% confidence interval [CI] 0.58\u20131.48,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.74), 0.57 (95% CI, 0.27\u20131.22,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.15), 1.06 (95% CI, 0.62\u20131.82,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.83) and 0.95 (95% CI, 0.42\u20132.17,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.91) respectively. Acute GVHD grade III\u2013IV and extensive chronic GVHD were associated with higher NRM (hazard ratio [HR] 1.95 [95% CI, 1.09\u20133.48,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002] and 3.3 [95% CI, 1.41\u20137.73,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006]) and reduced OS (HR 1.91 [95% CI, 1.07\u20133.39,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03] and 3.27 [95% CI, 1.4\u20137.66,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006]) respectively. In conclusion, acute and chronic GVHD are not statistically associated with reduced RI after haploSCT with PTCy in ALL. Higher GVHD grades are associated with higher NRM and lower OS.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70101","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T10:58:59Z","timestamp":1755169139000},"page":"2041-2048","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Graft\u2010versus\u2010host disease is not associated with reduced incidence of relapse following haploidentical stem cell transplantation with post\u2010transplant cyclophosphamide for acute lymphoblastic leukaemia: A study on behalf of the Acute Leukaemia Working Party of European Society for Blood and Marrow Transplantation"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8782-6160","authenticated-orcid":false,"given":"Avichai","family":"Shimoni","sequence":"first","affiliation":[{"name":"Division of Hematology, Chaim Sheba Medical Center, Tel\u2010Hashomer and Gray Faculty of Medical &amp; Health Sciences, Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Peczynski","sequence":"additional","affiliation":[{"name":"Sorbonne University, INSERM UMRs 938  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Labopin","sequence":"additional","affiliation":[{"name":"Sorbonne University, INSERM UMRs 938  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alida","family":"Dominietto","sequence":"additional","affiliation":[{"name":"UO Ematologia e Terapie Cellulari, IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariya","family":"Koc","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Unit, Medicana International Hospital Istanbul  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2039-8557","authenticated-orcid":false,"given":"Mutlu","family":"Arat","sequence":"additional","affiliation":[{"name":"Hematology and Hematopoietic SCT Unit, Sisli Memorial Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1821-1976","authenticated-orcid":false,"given":"Johanna","family":"Tischer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III University Hospital of Munich\u2010Campus Grosshadern, LMU  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Sica","sequence":"additional","affiliation":[{"name":"Universita Cattolica S. Cuore, Istituto di Ematologia, Ematologia  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zafer","family":"G\u00fclbas","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Department Anadolu Medical Center Hospital  Kocaeli Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2114-7533","authenticated-orcid":false,"given":"Gerard","family":"Soci\u00e9","sequence":"additional","affiliation":[{"name":"Department of Hematology \u2013 BMT Hopital St. Louis  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Blaise","sequence":"additional","affiliation":[{"name":"Programme de Transplantation and Therapie Cellulaire, Centre de Recherche en Canc\u00e9rologie de Marseille, Institut Paoli Calmettes  Marseille 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