{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:31:15Z","timestamp":1783020675004,"version":"3.54.6"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010167","name":"Shanghai Shen Kang Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC2020CR1012B"],"award-info":[{"award-number":["SHDC2020CR1012B"]}],"id":[{"id":"10.13039\/501100010167","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570148"],"award-info":[{"award-number":["81570148"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Relapse remains the primary cause of transplant failure in T\u2010cell lymphoblastic lymphoma (T\u2010LBL) after allogeneic haematopoietic stem cell transplantation (allo\u2010HSCT), yet prognostic data are scarce. We conducted a multicentre retrospective study of 104 adult T\u2010LBL patients in complete metabolic remission (CMR) undergoing allo\u2010HSCT. Pretransplant Deauville score (DS) was evaluated, and a risk model integrating DS, immunophenotype and donor type was developed. Patients with DS of 3 had significantly inferior 2\u2010year overall survival (OS) (70.5% vs. 77.4% vs. 86.8%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), progression\u2010free survival (PFS) (51.5% vs. 73.0% vs. 81.1%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and higher relapse rates (42.1% vs. 15.4% vs. 9.8%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) compared to DS of 1\u20132. Multivariable analysis identified pretransplant DS, immunophenotype and donor type as independent risk factors for post\u2010transplant relapse. These variables were integrated to construct a novel risk model stratifying patients into low\u2010 (66.0%), intermediate\u2010 (21.3%) and high\u2010risk (12.7%) groups, strongly discriminating OS (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), PFS (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and relapse (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), with a C\u2010index of 0.706. Internal validation confirmed that the risk stratification model had good discrimination, calibration and clinical benefit. Our findings propose a clinically actionable tool to identify high\u2010risk T\u2010LBL patients for tailored post\u2010transplant strategies.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70102","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T11:22:33Z","timestamp":1756207353000},"page":"2006-2016","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comprehensive risk stratification for adult T\u2010cell lymphoblastic lymphoma undergoing allogeneic haematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"207","author":[{"given":"Fangfang","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Hematology Shanghai General Hospital, Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Hematology The 960th Hospital of the Chinese People's Liberation Army Joint Logistics Support Force  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Hu","sequence":"additional","affiliation":[{"name":"Blood and Marrow Transplantation Center Shanghai Institute of Hematology, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erlie","family":"Jiang","sequence":"additional","affiliation":[{"name":"Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8290-3104","authenticated-orcid":false,"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2960-3131","authenticated-orcid":false,"given":"Ying","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated People's Hospital of Ningbo University  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1111-9141","authenticated-orcid":false,"given":"Xiaoyu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Division of Life Sciences and Medicine University of Science and Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangbo","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Hematology Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai 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