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G protein\u2010coupled receptor class C group 5 member D (\n                    <jats:italic>GPRC5D<\/jats:italic>\n                    ) has emerged as a promising immunotherapeutic target due to its high and selective expression in MM cells and minimal presence in normal tissues. This review outlines the structural features and expression profile of\n                    <jats:italic>GPRC5D<\/jats:italic>\n                    , emphasizing its relevance to disease biology and prognosis. We highlight recent advances in GPRC5D\u2010targeted therapies, including antibody\u2013drug conjugates (ADCs), bispecific and trispecific antibodies and chimeric antigen receptor T (CAR T)\/natural killer (NK)\u2010cell therapies, all demonstrating encouraging efficacy in relapsed\/refractory MM. Key challenges, such as antigen escape and the need for optimized combination strategies, are also discussed. As GPRC5D\u2010targeted agents advance through clinical development, large\u2010scale prospective trials will be essential to define their therapeutic positioning and improve patient outcomes. GPRC5D is poised to become a leading next\u2010generation target in MM immunotherapy following B\u2010cell maturation antigen.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70116","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T11:39:31Z","timestamp":1756467571000},"page":"1765-1778","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Emerging role of G protein\u2010coupled receptor class C group 5 member D\u2010directed immunotherapy in multiple myeloma: Advances, resistance and combination strategies"],"prefix":"10.1111","volume":"207","author":[{"given":"Xueting","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematology, Henan Institute of Hematology The Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital  Zhengzhou 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