{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T03:59:47Z","timestamp":1791604787053,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai Municipality","doi-asserted-by":"publisher","award":["22ZR1411400"],"award-info":[{"award-number":["22ZR1411400"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["HG2023\u2010001"],"award-info":[{"award-number":["HG2023\u2010001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Light\u2010chain cardiac amyloidosis (AL\u2010CA) causes structural and functional cardiac impairment. Myocardial work (MW), integrating left ventricular strain with afterload, may improve risk stratification. This study assesses the prognostic value of MW in AL\u2010CA patients and its potential to enhance traditional staging models. We prospectively enrolled biopsy\u2010confirmed AL\u2010CA patients between 2022 and 2024. MW indices, including global work index (GWI) and global constructive work (GCW), were derived using EchoPAC 206. The primary outcome was all\u2010cause mortality. Among 96 AL\u2010CA patients (mean age: 62.8\u2009\u00b1\u200910.2\u2009years; 70% male), 28 died during a median follow\u2010up of 190\u2009days. Multivariate Cox analysis identified GWI and GCW as independent predictors of mortality after adjusting for creatinine, heart rate, New York Heart Association class, Mayo 2012 class and pleural effusion. Kaplan\u2013Meier analysis showed worse survival for GWI \u2264840\u2009mmHg% or GCW \u22641031\u2009mmHg%. The likelihood ratio\n                    <jats:italic>\u03c7<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    test demonstrated that GWI and GCW significantly improved the predictive power of the Mayo 2012 and Euro 2015 models (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). MW indices, particularly GWI and GCW, are independent predictors of short\u2010term mortality in AL\u2010CA patients, thereby improving existing risk models and providing valuable prognostic insights.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70122","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T01:28:49Z","timestamp":1758245329000},"page":"1962-1972","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Myocardial work indices in the short\u2010term prognosis of light\u2010chain cardiac amyloidosis: Incremental value beyond traditional staging models and echocardiographic parameters"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5794-1563","authenticated-orcid":false,"given":"Fangmin","family":"Meng","sequence":"first","affiliation":[{"name":"Shanghai Institute of Medical Imaging Zhongshan Hospital, Fudan University  Shanghai China"},{"name":"Department of Echocardiography Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Haematology Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Medicine John H. Stroger, Jr. Hospital of Cook County  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanfeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Echocardiography Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Medical Imaging Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Yang","sequence":"additional","affiliation":[{"name":"Shanghai Medical College Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Haematology Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nianwei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Echocardiography Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Echocardiography Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dehong","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Echocardiography Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Echocardiography Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianhong","family":"Shu","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Medical Imaging Zhongshan Hospital, Fudan University  Shanghai China"},{"name":"Department of Echocardiography Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9639-6606","authenticated-orcid":false,"given":"Peng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Haematology Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuizhen","family":"Pan","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Medical Imaging Zhongshan Hospital, Fudan University  Shanghai China"},{"name":"Department of Echocardiography Zhongshan Hospital, Fudan University  Shanghai 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