{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:55:32Z","timestamp":1791327332982,"version":"4.3.1"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Anti\u2010thymocyte globulin (ATG) and post\u2010transplant cyclophosphamide (PTCy) are both effective drugs for graft\u2010versus\u2010host disease (GvHD) prophylaxis, but their combined use remains underexplored. We conducted a retrospective analysis of 582 patients with haematological malignancies who underwent unrelated donor transplantation with Status GvHD prophylaxis consisting of low\u2010dose ATG (2\u2009mg\/kg) and PTCy over a 10\u2010year period. The median time to neutrophil and platelet engraftment was 18\u2009days (95% CI, 17\u201319) and 20\u2009days (95% CI, 19\u201321) respectively. The cumulative incidence of grade III\u2013IV acute Status GvHD at D+100 was 7% (95% CI: 5\u20139), and the 24\u2010month incidence of moderate\u2010to\u2010severe chronic GvHD was 15.7% (95% CI: 13\u201319). Clinically significant cytomegalovirus (CMV) and Epstein\u2013Barr virus (EBV) reactivation by D+180 occurred in 20.4% (95% CI: 17\u201324) and 22.7% (95% CI: 19\u201326) respectively. At 24\u2009months, the cumulative incidence of NRM was 16.2% (95% CI: 13\u201319), and relapse was 21.3% (95% CI: 18\u201325). Graft\u2010versus\u2010host disease\u2010free, relapse\u2010free survival (GRFS) at 24\u2009months was 49% (95% CI: 44\u201353), and overall survival (OS) was 68.3% (95% CI: 64\u201372). Our decade\u2010long experience supports the safety and efficacy of combining low\u2010dose ATG with PTCy for GvHD prophylaxis in unrelated donor transplantation. These findings warrant further validation in prospective studies.<\/jats:p>","DOI":"10.1111\/bjh.70124","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:24:12Z","timestamp":1756279452000},"page":"2049-2058","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A decade of experience using\n                    <scp>ATG<\/scp>\n                    and\n                    <scp>PTCy<\/scp>\n                    for graft\u2010versus\u2010host disease prophylaxis in matched unrelated donor allogeneic haematopoietic cell transplantation"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1055-3245","authenticated-orcid":false,"given":"Nihar","family":"Desai","sequence":"first","affiliation":[{"name":"Hans Messner Allogeneic Blood and Marrow Transplant Program, Division of Medical Oncology and Haematology Princess Margaret Cancer Centre  Toronto Ontario 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