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We evaluated subtype\u2010specific PRSs, based on established EA\u2010SNPs, in Israeli Jews (IJ) and Palestinian Arabs (PA) and performed a GWAS in the combined ethnic groups to identify new loci. We included three common pathologically confirmed subtypes: diffuse large B\u2010cell (DLBCL), follicular (FL) and marginal zone (MZL) lymphomas. Controls were frequency matched to cases by age and sex. Among 752 IJ (201\u2014DLBCL; 130\u2014FL; 54\u2014MZL\/367\u2014controls) and 593 PA (203\u2014DLBCL; 41\u2014FL\/349\u2010controls), we computed PRSs weighted by EA\u2010derived effect estimates and used logistic regression models adjusted for confounders. In the combined ethnic groups of IJ and PA, subtype\u2010specific PRSs were significantly associated with the corresponding subtype, with a 1.69\u2010fold, 2.21\u2010fold and 2.26\u2010fold risk for DLBCL, FL and MZL, respectively; however, these effect sizes were attenuated compared to those reported in EA and varied by ethnicity. In the GWAS of the combined ethnic groups, two novel SNPs in the 6p21.32 locus were associated with DLBCL risk. Additional GWAS studies are needed among Jewish and Arab populations to improve genetic risk prediction for NHL in these ethnic groups.<\/jats:p>","DOI":"10.1111\/bjh.70125","type":"journal-article","created":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T23:34:42Z","timestamp":1756683282000},"page":"1832-1841","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["European\u2010based polygenic risk score and genome\u2010wide association study of B\u2010cell non\u2010Hodgkin lymphoma subtypes in Israeli Jews and Palestinian Arabs"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6148-0421","authenticated-orcid":false,"given":"Geffen","family":"Kleinstern","sequence":"first","affiliation":[{"name":"Faculty of Social Welfare and Health Sciences, School of Public Health University of Haifa  Haifa Israel"},{"name":"Department of Quantitative Health Sciences Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis P.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania","family":"Abu Seir","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences Al\u2010Quds University  Jerusalem Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riki","family":"Perlman","sequence":"additional","affiliation":[{"name":"Department of Hematology Hadassah Medical Organization  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of Human Genomics, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)  Singapore Republic of Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore Republic of Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidal","family":"Jebrini","sequence":"additional","affiliation":[{"name":"Beit\u2010Jala Hospital  Bethlehem Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein","family":"Elyan","sequence":"additional","affiliation":[{"name":"Husein Hematology and Lymphoma Clinic  Bethlehem Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina","family":"Ben Yehuda","sequence":"additional","affiliation":[{"name":"Department of Hematology Hadassah Medical Organization  Jerusalem Israel"},{"name":"Faculty of Medicine The Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Slager","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Mayo Clinic  Rochester Minnesota USA"},{"name":"Division of Hematology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8324-3873","authenticated-orcid":false,"given":"Ora","family":"Paltiel","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Braun School of Public Health and Community Medicine Hadassah\u2010Hebrew University  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201001\u2010643569"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1059914"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.34163"},{"key":"e_1_2_10_5_1","unstructured":"Population of Israelis by religion. 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