{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T14:17:27Z","timestamp":1767968247622,"version":"3.49.0"},"reference-count":60,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Childhood acute lymphoblastic leukaemia (chALL) remains the most prevalent malignancy in children and adolescents. Improving risk stratification and providing personalized prognosis and treatment remain major clinical challenges. Herein, we analysed the clinical utility of NEAT1 lncRNA for the prognosis and prediction of treatment outcome of childhood B\u2010cell precursor ALL (chB\u2010ALL). NEAT1_1 isoform was quantified in bone marrow samples of chB\u2010ALL patients at diagnosis (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009160) and at the end of induction (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009108) of ALL\u2010BFM protocol, and in age\u2010matched healthy children (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200968). Relapse and death served as clinical end\u2010points for survival analysis. Bootstrap analysis was performed for internal validation and decision curve analysis assessed the clinical net benefit for chB\u2010ALL prognosis. Our analysis showed that chB\u2010ALL patients with NEAT1 overexpression at diagnosis are at significantly higher risk for progression (HR\u2009=\u20092.957, 95% CI: 1.122\u20137.790,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.011) and worse survival (HR\u2009=\u20095.832, 95% CI: 1.259\u201327.01,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.012), independently of clinicopathological and treatment data. Moreover, NEAT1\u2010fitted multivariate models resulted in improved risk stratification compared to the conventional disease markers of white blood cells, bone marrow response and minimal residual disease, while decision curve analysis highlighted the superior clinical net benefit for chB\u2010ALL prognosis. In conclusion, NEAT1 overexpression constitutes a powerful, independent predictor of poor treatment outcomes and disease progression of chB\u2010ALL, providing refined stratification of patient's risk.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70127","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T09:52:16Z","timestamp":1756720336000},"page":"2475-2485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>NEAT1 lncRNA<\/scp>\n                    overexpression results in short\u2010term progression and poor treatment outcome in childhood B\u2010\n                    <scp>ALL<\/scp>"],"prefix":"10.1111","volume":"207","author":[{"given":"Marieta","family":"Xagorari","sequence":"first","affiliation":[{"name":"Laboratory of Clinical Biochemistry\u2014Molecular Diagnostics, Second Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, \u2018P. &amp; A. Kyriakou\u2019 Children's Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonios","family":"Marmarinos","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Biochemistry\u2014Molecular Diagnostics, Second Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, \u2018P. &amp; A. Kyriakou\u2019 Children's Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Doganis","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology \u2018P. &amp; A. Kyriakou\u2019 Children's Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Nikita","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology \u2018P. &amp; A. Kyriakou\u2019 Children's Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgenia","family":"Magkou","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology \u2018P. &amp; A. Kyriakou\u2019 Children's Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angeliki\u2010Eleni","family":"Sfetsiori","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology \u2018P. &amp; A. Kyriakou\u2019 Children's Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarita","family":"Baka","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology \u2018P. &amp; A. Kyriakou\u2019 Children's Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia","family":"Kossiva","sequence":"additional","affiliation":[{"name":"Second Department of Pediatrics, School of Medicine National and Kapodistrian University of Athens, \u2018P. &amp; A. Kyriakou\u2019 Children's Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Pasparaki","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Biochemistry\u2014Molecular Diagnostics, Second Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, \u2018P. &amp; A. Kyriakou\u2019 Children's Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Soldatou","sequence":"additional","affiliation":[{"name":"Second Department of Pediatrics, School of Medicine National and Kapodistrian University of Athens, \u2018P. &amp; A. Kyriakou\u2019 Children's Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Tsolia","sequence":"additional","affiliation":[{"name":"Second Department of Pediatrics, School of Medicine National and Kapodistrian University of Athens, \u2018P. &amp; A. Kyriakou\u2019 Children's Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2427-4949","authenticated-orcid":false,"given":"Andreas","family":"Scorilas","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Faculty of Biology, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Gourgiotis","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Biochemistry\u2014Molecular Diagnostics, Second Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, \u2018P. &amp; A. 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