{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:32:07Z","timestamp":1783020727238,"version":"3.54.6"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100018552","name":"Science and Technology Plan Project of Taizhou","doi-asserted-by":"publisher","award":["24ywb02"],"award-info":[{"award-number":["24ywb02"]}],"id":[{"id":"10.13039\/501100018552","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Acute lysis pneumopathy (ALP) is a rare but fatal complication that can occur during induction chemotherapy for newly diagnosed acute myeloid leukaemia (AML). Currently, there is a paucity of large case reports detailing high\u2010risk and poor prognostic factors associated with its occurrence. To provide evidence\u2010based guidance on ALP, we conducted a retrospective analysis of 608 patients with newly diagnosed AML (non\u2010M3), among whom 20 developed ALP during hydroxycarbamide (hydroxyurea) therapy and\/or induction chemotherapy, resulting in an overall incidence rate of 3.3% (20\/608) and a mortality rate of 35% (7\/20). Multivariable logistic regression revealed that male (odds ratio [OR] 5.852, 95% confidence interval [CI]: 1.006\u201334.028,\n                    <jats:italic>p\u2009=<\/jats:italic>\n                    \u20090.049), elevated leucocyte counts (OR 1.125, 95% CI: 1.050\u20131.205,\n                    <jats:italic>p\u2009=<\/jats:italic>\n                    \u20090.001) and\n                    <jats:italic>CBF\u03b2::MYH11<\/jats:italic>\n                    fusion positivity (OR 13.821, 95% CI: 3.002\u201363.634,\n                    <jats:italic>p\u2009=<\/jats:italic>\n                    \u20090.001) were independent risk factors for the occurrence of ALP. Notably,\n                    <jats:italic>CBF\u03b2::MYH11<\/jats:italic>\n                    fusion positivity was associated with improved survival in ALP patients (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.015). This study provides preliminary insights into the risk and prognostic factors of ALP.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70129","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T05:58:52Z","timestamp":1756706332000},"page":"1944-1952","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The role of\n                    <i>CBF\u03b2::MYH11<\/i>\n                    fusion gene in acute lysis pneumopathy: A dual impact on risk and prognosis"],"prefix":"10.1111","volume":"207","author":[{"given":"Shuangwei","family":"Ying","sequence":"first","affiliation":[{"name":"Bone Marrow Transplantation Center of the First Affiliated Hospital &amp; Liangzhu Laboratory Zhejiang University School of Medicine  Hangzhou Zhejiang China"},{"name":"Department of Hematology Taizhou Hospital of Zhejiang Province, Affiliated to Wenzhou Medical University  Linhai China"},{"name":"Institute of Hematology, Zhejiang University  Hangzhou Zhejiang China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luxin","family":"Yang","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center of the First Affiliated Hospital &amp; Liangzhu Laboratory Zhejiang University School of Medicine  Hangzhou Zhejiang China"},{"name":"Institute of Hematology, Zhejiang University  Hangzhou Zhejiang China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Affiliated Hospital of Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruimin","family":"Hong","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center of the First Affiliated Hospital &amp; Liangzhu Laboratory Zhejiang University School of Medicine  Hangzhou Zhejiang China"},{"name":"Institute of Hematology, Zhejiang University  Hangzhou Zhejiang China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenda","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Hematology Taizhou Hospital of Zhejiang Province, Affiliated to Wenzhou Medical University  Linhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Hematology Taizhou Hospital of Zhejiang Province, Affiliated to Wenzhou Medical University  Linhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7835-3656","authenticated-orcid":false,"given":"Jie","family":"Sun","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center of the First Affiliated Hospital &amp; Liangzhu Laboratory Zhejiang University School of Medicine  Hangzhou Zhejiang China"},{"name":"Institute of Hematology, Zhejiang University  Hangzhou Zhejiang China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunyi","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Hematology Taizhou Hospital of Zhejiang Province, Affiliated to Wenzhou Medical University  Linhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7051-219X","authenticated-orcid":false,"given":"Yi","family":"Luo","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center of the First Affiliated Hospital &amp; Liangzhu Laboratory Zhejiang University School of Medicine  Hangzhou Zhejiang China"},{"name":"Institute of Hematology, Zhejiang University  Hangzhou Zhejiang China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-010-0746-y"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e31827b4702"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2015.03.007"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-15742-4_39"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19821215)50:12<2763::AID-CNCR2820501212>3.0.CO;2-R"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20192"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920315)69:6<1356::AID-CNCR2820690609>3.0.CO;2-B"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02043.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V60.2.279.279"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.7.2121"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-15742-4_61"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2021.100926"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-022-01638-1"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197411000-00006"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.5.3629"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16278"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2002.02802.x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428190309178819"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24711"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.8.2712"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00057711"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70129","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.70129","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:08:15Z","timestamp":1783015695000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.70129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,31]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/bjh.70129"],"URL":"https:\/\/doi.org\/10.1111\/bjh.70129","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,31]]},"assertion":[{"value":"2025-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}