{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:29:15Z","timestamp":1783020555287,"version":"3.54.6"},"reference-count":67,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000902","name":"Pediatric Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000902","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015521","name":"Stanford Maternal and Child Health Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015521","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Chronic myeloid leukaemia (CML) accounts for 2% of leukaemias in children and 9% in adolescents. While the BCR::ABL1 fusion gene remains a hallmark across all age groups, emerging evidence suggests that paediatric CML exhibits unique biological and clinical characteristics compared to its adult counterpart. Children often present with more aggressive clinical features and show distinct treatment response patterns. Recent genomic and transcriptomic studies have highlighted a higher prevalence of germline variants in haematopoiesis\u2010related genes and unique cytogenetic alterations, as well as age\u2010specific distributions of BCR and ABL1 breakpoints. Transcriptomic profiling of paediatric CML stem cells reveals differential expression signatures that suggest the presence of distinct signalling networks. Somatic mutations\u2014particularly in ASXL1\u2014are observed at diagnosis in some children, though their prognostic relevance remains uncertain. Additionally, while the BCR::ABL1 transcript subtype is known to affect treatment\u2010free remission in adults, its role in paediatric CML is still unclear. Collectively, these findings support the notion that paediatric CML may constitute a biologically distinct disease rather than simply a younger form of adult CML. To advance risk stratification and develop age\u2010specific treatment approaches, larger international studies and comprehensive genomic analyses are urgently needed.<\/jats:p>","DOI":"10.1111\/bjh.70134","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T02:05:45Z","timestamp":1757383545000},"page":"1782-1788","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["An old leukaemia in young patients\u2014Genetic characteristics of paediatric chronic myeloid leukaemia"],"prefix":"10.1111","volume":"207","author":[{"given":"Markus","family":"Metzler","sequence":"first","affiliation":[{"name":"Pediatric Oncology and Hematology, Department of Pediatrics and Adolescent Medicine University Hospital Erlangen  Erlangen Germany"},{"name":"Comprehensive Cancer Center Erlangen\u2010EMN (CCC ER\u2010EMN)  Erlangen Germany"},{"name":"Bavarian Cancer Research Center (BZKF)  Erlangen 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