{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:30:22Z","timestamp":1783020622231,"version":"3.54.6"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Refractory cytomegalovirus (CMV) infection is a severe complication following umbilical cord blood transplantation (UCBT). Antiviral agents, the standard first\u2010line therapy, are limited by toxicity and resistance without robust T\u2010cell immunity. We evaluated third\u2010party donor (TPD)\u2010derived CMV\u2010specific T cells (CMVSTs) as a treatment option. In a prospective phase I trial, UCBT recipients under 60\u2009years with refractory CMV infection were enrolled. CMV\u2010seropositive TPDs, matched for at least one human leucocyte antigen (HLA) class I allele at high resolution, were selected from family members. CMVSTs were manufactured for two infusions within 1\u2009month. Safety and feasibility were primary end\u2010points while efficacy and immune reconstitution were secondary end\u2010points. Ten patients (median age: 15.5\u2009years, range: 3\u201346\u2009years) received CMVSTs (median doses: 2.2\u2009\u00d7\u200910\n                    <jats:sup>7<\/jats:sup>\n                    \/m\n                    <jats:sup>2<\/jats:sup>\n                    and 4.2\u2009\u00d7\u200910\n                    <jats:sup>7<\/jats:sup>\n                    \/m\n                    <jats:sup>2<\/jats:sup>\n                    ). Products showed high CD3\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell purity and memory T\u2010cell dominance. Infusions caused mild adverse events, with no severe toxicities. At 6\u2009months post\u2010first infusion, 80% (8\/10) achieved durable virological clearance; 60% (6\/10) survived at 2\u2009years with sustained CMV control. TPD\u2010derived CMVST infusions are safe and feasible for refractory CMV infection post\u2010UCBT, offering durable virological control while larger studies are needed to confirm efficacy. This trial was registered at\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.chictr.org.cn\">www.chictr.org.cn<\/jats:ext-link>\n                    as # ChiCTR2000034951.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70136","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T03:50:15Z","timestamp":1757562615000},"page":"2072-2079","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Adoptive transfer of third\u2010party donor\n                    <scp>CMV<\/scp>\n                    \u2010specific T cells for refractory cytomegalovirus infection following umbilical cord blood transplantation"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9101-0463","authenticated-orcid":false,"given":"Guangyu","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwei","family":"Tu","sequence":"additional","affiliation":[{"name":"Shanghai iCELL Biotechnology Co., Ltd.  Shanghai China"},{"name":"Shanghai Engineering Research Center of Stem Cells Translational Medicine  Shanghai China"},{"name":"Institute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Life Sciences and Technology Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baolin","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyi","family":"Lu","sequence":"additional","affiliation":[{"name":"Shanghai iCELL Biotechnology Co., Ltd.  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