{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:31:21Z","timestamp":1783020681470,"version":"3.54.6"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Mastocytosis is categorized into cutaneous mastocytosis (CM), mast cell sarcoma and systemic mastocytosis (SM). Within SM, indolent SM (ISM) is the more frequent subtype. Adult patients with CM but without an extracutaneous biopsy are classified as having mastocytosis in the skin (MIS), a provisional diagnosis. Mastocytosis patients may experience a wide range of symptoms that significantly impact their quality of life (QoL). In France, the estimated prevalence of mastocytosis and the burden of symptoms remain unknown. To address this, we conducted a national online survey to estimate the number of mastocytosis diagnoses and assess the burden of symptoms from the physician's perspective. Overall, 1169 of the 6239 physicians solicited completed the survey. These physicians reported managing 4121 patients of whom only 53% had ISM. By contrast, CM and MIS were reported in more patients than expected at 17% and 25% respectively. The estimated prevalence of mastocytosis in France was 8.5 per 100,000, which is lower than recent epidemiological studies and is associated with significant regional variability (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Among patients with ISM or MIS, 53% experienced moderate to severe symptoms\u2014mainly affecting the skin, digestive system and general health\u2014which impacted most QoL domains assessed. These findings highlight the need to improve awareness, access to diagnostic workup for mastocytosis (especially for patients with MIS and CM) and enhance QoL for patients.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70148","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T01:29:40Z","timestamp":1757554180000},"page":"1973-1981","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnosis, management and the burden of symptoms of mastocytosis from the physician's perspective: A nationwide study"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3052-1424","authenticated-orcid":false,"given":"Julien","family":"Rossignol","sequence":"first","affiliation":[{"name":"French Reference Center for Mastocytosis (CEREMAST), Necker\u2010Enfants Malades University Hospital, APHP  Paris France"},{"name":"Paris University, Imagine Institute, INSERM U1163, Necker\u2010Enfants Malades University Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Bouillet","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Grenoble Alpes University Hospital, University Grenoble Alpes, T\u2010RAIG Unit, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, CHU Grenoble Alpes, TIMC  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Bulai\u2010Livideanu","sequence":"additional","affiliation":[{"name":"CEREMAST Toulouse, Dermatology Department CHU de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Barete","sequence":"additional","affiliation":[{"name":"French Reference Center for Mastocytosis (CEREMAST), Necker\u2010Enfants Malades University Hospital, APHP  Paris France"},{"name":"Sorbonne Universit\u00e9, APHP Unit\u00e9 Fonctionnelle de Dermatologie, Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re\u2010C, Foix  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Bruneau","sequence":"additional","affiliation":[{"name":"Paris University, Imagine Institute, INSERM U1163, Necker\u2010Enfants Malades University Hospital  Paris France"},{"name":"Department of Pathology Necker\u2010Children's Hospital, AP\u2010HP, Paris Centre University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9ment","family":"Gourguechon","sequence":"additional","affiliation":[{"name":"Department of Hematology Amiens University Hospital  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Polivka","sequence":"additional","affiliation":[{"name":"Paris University, Imagine Institute, INSERM U1163, Necker\u2010Enfants Malades University Hospital  Paris France"},{"name":"Department of Dermatology, Reference Center for Genodermatoses (MAGEC), Necker Hospital for Sick Children, Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP) Paris Cit\u00e9 University  Paris France"},{"name":"CEREMAST, the Department of Hematology Necker\u2010Children's Hospital, AP\u2010HP, Paris Centre University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e8le","family":"Soria","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Tenon Hospital, Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Lortholary","sequence":"additional","affiliation":[{"name":"French Reference Center for Mastocytosis (CEREMAST), Necker\u2010Enfants Malades University Hospital, APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor","family":"Stanbury","sequence":"additional","affiliation":[{"name":"Pro\u2010Pens  Antony France"},{"name":"Carely  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Bouquillon","sequence":"additional","affiliation":[{"name":"Carely  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedric","family":"Sauvage","sequence":"additional","affiliation":[{"name":"Carely  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose Marie","family":"Javier","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Competence Center for Rare Genetic Bone Disorders University\u2010Hospital of Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Hermine","sequence":"additional","affiliation":[{"name":"French Reference Center for Mastocytosis (CEREMAST), Necker\u2010Enfants Malades University Hospital, APHP  Paris France"},{"name":"Paris University, Imagine Institute, INSERM U1163, Necker\u2010Enfants Malades University Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Arock","sequence":"additional","affiliation":[{"name":"Platform of Molecular Analysis for Mastocytosis and MCAD (CEREMAST), Department of Biological Hematology, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, AP\u2010HP, Paris Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the CEREMAST 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