{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:30:14Z","timestamp":1783020614825,"version":"3.54.6"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T00:00:00Z","timestamp":1757808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T00:00:00Z","timestamp":1757808000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2023IF0001\u20101"],"award-info":[{"award-number":["2023IF0001\u20101"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Blood inflammatory markers may provide prognostic insights but remain underexplored in mycosis fungoides (MF). To evaluate the prognostic significance of baseline blood inflammatory markers, including the neutrophil\u2010to\u2010lymphocyte ratio (NLR), eosinophil\u2010to\u2010lymphocyte ratio (ELR), monocyte\u2010to\u2010lymphocyte ratio (MLR), pan\u2010inflammation value (PIV) and systemic immune\u2010inflammation index (SII), in MF. This retrospective cohort study included MF patients diagnosed between 1997 and 2024 at a tertiary medical centre. Markers were analysed in relation to MF stage, morphology, overall survival (OS) and progression\u2010free survival (PFS). Among 195 patients, all markers were significantly elevated in advanced\u2010stage MF compared to early\u2010stage MF. Marker levels generally increased from patch to tumour\u2010stage MF but did not distinguish erythrodermic MF from tumour MF. All markers were associated with poor survival outcomes in univariable analysis. However, in multivariable analysis, only PIV and SII independently associated with poor OS and PFS. Patients with high PIV or SII were more likely to exhibit poor prognostic factors, including advanced stage, head and neck involvement and elevated serum lactate dehydrogenase levels, and experienced more frequent disease progression during follow\u2010up. Single\u2010centre retrospective design. Baseline PIV and SII can be significant prognostic markers in MF, offering enhanced risk stratification and guiding clinical management.<\/jats:p>","DOI":"10.1111\/bjh.70151","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T04:20:03Z","timestamp":1757910003000},"page":"1902-1911","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Systemic immune\u2010inflammation index and pan\u2010immune value as prognostic indicators of clinical outcomes in mycosis fungoides: A retrospective cohort study"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3432-8306","authenticated-orcid":false,"given":"Joon Min","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Dermatology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7514-7873","authenticated-orcid":false,"given":"Myoung Eun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1123-4166","authenticated-orcid":false,"given":"Ik Jun","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1997-2240","authenticated-orcid":false,"given":"Chong Hyun","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4225-0414","authenticated-orcid":false,"given":"Sung Eun","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4669-9454","authenticated-orcid":false,"given":"Mi Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0549-464X","authenticated-orcid":false,"given":"Woo Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-10-184168"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.7.857"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1996.03890350051009"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.27.7665"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-055749"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.03.056"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-024-03496-x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljad423"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2022.2043303"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-024-02909-1"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.7142"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.12.064"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-016-0794-1"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16291"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-6660-x"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000001731"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22964"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000494259"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1182944"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S245928"},{"issue":"1","key":"e_1_2_12_23_1","first-page":"25","article-title":"Prognostic evaluation of neutrophil\/lymphocyte ratio in patients with mycosis fungoides","volume":"47","author":"Cengiz FP","year":"2017","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13111979"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-016-2779-7"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2018.12.020"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2015.1057894"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051862"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2025.115484"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12307-014-0147-5"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00571-6"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-94184-7"},{"issue":"10","key":"e_1_2_12_33_1","first-page":"5277","article-title":"STAT3 activation and infiltration of eosinophil granulocytes in mycosis fungoides","volume":"34","author":"Fredholm S","year":"2014","journal-title":"Anticancer Res"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.07.017"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21006"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21982"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.18125"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70151","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.70151","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:09:29Z","timestamp":1783015769000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.70151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,14]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/bjh.70151"],"URL":"https:\/\/doi.org\/10.1111\/bjh.70151","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,14]]},"assertion":[{"value":"2025-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}