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C5 inhibitors are recommended as first\u2010line therapy for PNH with high disease activity. We retrospectively analysed 57 patients treated with eculizumab or crovalimab. Luminex\u00ae liquid\u2010phase chip technology was used to detect changes in complement and cytokine levels in patients pre\u2010 and post\u2010treatment. Haemolysis control (LDH\u2009\u2264\u20091.5\u2009\u00d7\u2009ULN) was achieved in 78.9% of patients, and 68.3% became transfusion\u2010independent. Mean haemoglobin rose from 76 to 99\u2009g\/L at week 24. Infections were the most common adverse events, but none were severe, and no discontinuations occurred. Post\u2010treatment, C5 and C5a levels increased significantly. Baseline levels of C5, C5a, C3, C1q, granulocyte colony\u2010stimulating factor (G\u2010CSF) and tumour necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) were higher in non\u2010responders than in responders or controls. Our findings confirm the efficacy and safety of C5 inhibitors in Chinese PNH patients and indicate that complement and cytokine profiles may serve as predictive biomarkers.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70156","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T07:31:13Z","timestamp":1759735873000},"page":"2109-2117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A single\u2010centre, real\u2010world study on the efficacy and recovery of inflammatory cytokine levels of C5 complement inhibitor therapy in patients with paroxysmal nocturnal haemoglobinuria"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9262-5371","authenticated-orcid":false,"given":"Mengting","family":"Che","sequence":"first","affiliation":[{"name":"Department of Hematology Tianjin Medical University General Hospital  Tianjin PR China"},{"name":"Tianjin Key Laboratory of Bone Marrow Failure and Malignant Hemopoietic Clone Control  Tianjin PR China"},{"name":"Tianjin Institute of Hematology  Tianjin PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6253-4169","authenticated-orcid":false,"given":"Chaomeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology Tianjin Medical University General Hospital  Tianjin PR China"},{"name":"Tianjin Key Laboratory of Bone Marrow Failure and Malignant Hemopoietic Clone Control  Tianjin PR China"},{"name":"Tianjin Institute of Hematology  Tianjin PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3400-6015","authenticated-orcid":false,"given":"Yongchun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology Tianjin Medical University General Hospital  Tianjin PR China"},{"name":"Tianjin Key Laboratory of Bone Marrow Failure and Malignant Hemopoietic Clone Control  Tianjin PR China"},{"name":"Tianjin Institute of Hematology  Tianjin PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2732-3646","authenticated-orcid":false,"given":"Liyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology Tianjin Medical University General Hospital  Tianjin PR China"},{"name":"Tianjin Key Laboratory of Bone Marrow Failure and Malignant Hemopoietic Clone Control  Tianjin PR China"},{"name":"Tianjin Institute of Hematology  Tianjin PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology Tianjin Medical University General Hospital  Tianjin PR China"},{"name":"Tianjin Key Laboratory of Bone Marrow Failure and Malignant Hemopoietic Clone Control  Tianjin PR China"},{"name":"Tianjin Institute of Hematology  Tianjin PR 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