{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T14:32:06Z","timestamp":1767969126545,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T00:00:00Z","timestamp":1757808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Population data have shown that the prognosis for elderly patients with acute lymphoblastic leukaemia (ALL) is poor, even in the modern era and despite improvements in the outcome for younger patients. In this Norwegian prospective population\u2010based study, the feasibility and effectiveness of a paediatric\u2010based regimen in newly diagnosed patients above 65\u2009years of age with ALL were assessed. Patients who were Philadelphia chromosome (Ph) negative were assigned to unmodified doses of pegylated asparaginase starting on day 30, while Ph\u2010positive patients were treated with imatinib. For frail patients, dose reductions were allowed at the discretion of the treating physician. A total of 52 patients were enrolled, 32 of whom were Ph negative. The median age was 70\u2009years (range 65\u201382). Forty\u2010nine attained remission, of which four did not receive further treatment and died. Six patients died while in remission and three died from a second malignancy. Among the remaining 36 patients, only six relapsed. The 2\u2010year and 5\u2010year overall survival rates, with a median follow\u2010up of 3.2\u2009years (Interquartile range 1.3\u20136.3), were 0.60 (95% confidence interval 0.46\u20130.74) and 0.50 (0.34\u20130.66) respectively. In conclusion, this paediatric\u2010based protocol was well tolerated and effective, with low relapse rates and 50% long\u2010term survival.<\/jats:p>","DOI":"10.1111\/bjh.70159","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T03:35:40Z","timestamp":1757907340000},"page":"2434-2440","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Improved outcomes in elderly patients with acute lymphoblastic leukaemia using a paediatric\u2010based protocol\u2014A prospective study"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6201-8548","authenticated-orcid":false,"given":"P.","family":"Quist\u2010Paulsen","sequence":"first","affiliation":[{"name":"Department of Hematology, St. Olav's Hospital Trondheim University Hospital  Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Horvei","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine University Hospital of North Norway  Troms\u00f8 Norway"},{"name":"Department of Clinical Medicine UiT\u2014The Arctic University of Norway  Troms\u00f8 Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Dalgaard","sequence":"additional","affiliation":[{"name":"Medical Department Drammen Hospital Vestreviken Trust  Drammen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Moksnes","sequence":"additional","affiliation":[{"name":"Cancer and Hematology Center Vestfold Hospital Trust  T\u00f8nsberg Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. L.","family":"Eilertsen","sequence":"additional","affiliation":[{"name":"Department of Hematology Akershus University Hospital  L\u00f8renskog Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Paulson","sequence":"additional","affiliation":[{"name":"Cancer and Hematology Center Vestfold Hospital Trust  T\u00f8nsberg Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. A.","family":"Azrakhsh","sequence":"additional","affiliation":[{"name":"Department of Haematology Haukeland University Hospital  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Majeed","sequence":"additional","affiliation":[{"name":"Department of Hematology Stavanger University Hospital  Stavanger Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. S.","family":"Wik","sequence":"additional","affiliation":[{"name":"Department of Hematology Oslo University Hospital  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.265"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-130237"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26156"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.230"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12896"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2018.1509318"},{"issue":"6","key":"e_1_2_8_8_1","article-title":"Results from UKALL60+, a phase 2 study in older patients with untreated acute lymphoblastic leukemia","volume":"8","author":"Patel B","year":"2024","journal-title":"Hema"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2012.09095.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.76.8192"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-022-01904-2"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.24.00490"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.00546"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01766"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2024-210983"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023023156"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12561"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2013.09.027"},{"key":"e_1_2_8_19_1","volume-title":"\u00c5rsrapport 2024 med resultater og forbedringstiltak fra Nasjonalt kvalitetsregister for lymfoide maligniteter","year":"2025"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-99-111954"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401310"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.5.1211"},{"issue":"10","key":"e_1_2_8_23_1","first-page":"3893","article-title":"Effective dose of L\u2010asparaginase for induction of remission in previously treated children with acute lymphocytic leukemia: a report from Childrens Cancer Study Group","volume":"39","author":"Ertel IJ","year":"1979","journal-title":"Cancer Res"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.219"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2006.00778.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2022-158934"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tru.2023.100155"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70159","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T11:44:20Z","timestamp":1767959060000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.70159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,14]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/bjh.70159"],"URL":"https:\/\/doi.org\/10.1111\/bjh.70159","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,14]]},"assertion":[{"value":"2025-05-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}