{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T03:34:19Z","timestamp":1789184059836,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA100632"],"award-info":[{"award-number":["CA100632"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:italic>MECOM<\/jats:italic>\n                    rearrangements (\n                    <jats:italic>MECOM<\/jats:italic>\n                    \u2010r) are acute myeloid leukaemia (AML)\u2010defining, regardless of blast percentage or\n                    <jats:italic>MECOM<\/jats:italic>\n                    fusion partner. We sought to investigate if blast percentage or\n                    <jats:italic>MECOM<\/jats:italic>\n                    \u2010r partner was associated with overall survival (OS). We included 152 adult patients with newly diagnosed\n                    <jats:italic>MECOM<\/jats:italic>\n                    \u2010r and classified blast percentage into &lt;20% or \u226520% and\n                    <jats:italic>MECOM<\/jats:italic>\n                    \u2010r partner into classic (\n                    <jats:italic>GATA2::MECOM<\/jats:italic>\n                    ) or variant (others). Thirty\u2010one per cent had &lt;20% blasts, with 69% having \u226520%; 57% had classic and 43% variant\n                    <jats:italic>MECOM<\/jats:italic>\n                    \u2010r. Treatment was with intensive chemotherapy (IC) in 41% and low\u2010intensity therapy (LIT) in 59%. Composite complete remission rates were similar between IC (50%) and LIT (48%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.99). The median OS was 17\u2009months (95% confidence interval [CI], 12\u2013not estimable [NE]) for &lt;20% blasts, compared with 9\u2009months (95% CI, 6\u201310) for \u226520% blasts (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). On multivariate analysis, \u226520% blasts were associated with worse OS (hazard ratio [HR] 1.9, [95% CI, 1.2\u20133.2],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01), independent of age,\n                    <jats:italic>MECOM<\/jats:italic>\n                    \u2010r partner, additional cytogenetic abnormalities, treatment intensity, addition of venetoclax and stem cell transplant (SCT). HR for IC was 2.0 (95% CI, 1.1\u20133.7,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03). In &lt;20% blasts, variant\n                    <jats:italic>MECOM<\/jats:italic>\n                    \u2010r was independently associated with a reduced hazard of death (HR 0.2 [95% CI, 0.1\u20130.8],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01).\n                    <jats:italic>MECOM<\/jats:italic>\n                    \u2010r AML is a heterogenous entity; consideration should be given to LIT approaches.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70171","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T01:55:30Z","timestamp":1758592530000},"page":"2451-2461","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<i>MECOM<\/i>\n                    fusion partner and bone marrow blast percentage influence outcomes of patients with\n                    <i>MECOM<\/i>\n                    rearranged acute myeloid leukaemia"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9339-3362","authenticated-orcid":false,"given":"Wei\u2010Ying","family":"Jen","sequence":"first","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilin","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eitan","family":"Kugler","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2634-4341","authenticated-orcid":false,"given":"Jennifer","family":"Croden","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9140-0610","authenticated-orcid":false,"given":"Koji","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Bazinet","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas 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C.","family":"Issa","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian M.","family":"Bouligny","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherry","family":"Pierce","sequence":"additional","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7592-2224","authenticated-orcid":false,"given":"Uday","family":"Popat","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center  Houston Texas 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