{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:41:57Z","timestamp":1792806117639,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:00:00Z","timestamp":1760832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:00:00Z","timestamp":1760832000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    CD7 Chimeric Antigen Receptor\u2010T cell (CAR\u2010T) therapy demonstrates efficacy in relapsed\/refractory (R\/R) acute T\u2010lymphoblastic leukaemia (ALL)T\u2010ALL\/lymphoblastic lymphoma (LBL), but concerns about T\u2010cell depletion and severe immunodeficiency persist. We compared infection rates and immune cell subsets in 60 R\/R T\u2010ALL\/LBL patients receiving naturally selected CD7 CAR\u2010T (NS7CAR\u2010T) with 60 R\/R B\u2010ALL patients undergoing CD19 CAR\u2010T. Infections were monitored from infusion until allogeneic haematopoietic stem cell transplantation (HSCT) or up to 3\u2009months. Overall infection rates did not significantly differ between groups (36.67% vs. 24.56%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.24), although the incidence of early immune effector cell\u2010associated haematotoxicity (ICAHT) grade III\u2013IV was higher in the CD7 CAR\u2010T group than in the CD19 CAR\u2010T group (33.9% vs. 16.7%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03). Post\u2010CD7 CAR\u2010T infusion analysis showed a significant decline in CD7(+) T cells and an increase in non\u2010CAR\u2010T\u2010derived CD7(\u2212) T cells, particularly non\u2010CAR\u2010T cells, which rose to a median proportion of 84.4% (range: 22.1%\u201399.9%) by day 28; meanwhile, CD7(\u2212) natural killer (NK) cells approached nearly 100% following the depletion of CD7(+) NK cells. This study indicates that while CD7 CAR\u2010T therapy significantly reduces CD7(+) T cells, it does not lead to increased short\u2010term infection rates. The notable expansion of non\u2010CAR\u2010T\u2010derived CD7(\u2212) T and NK cells helps preserve immune function, highlighting distinct therapeutic mechanisms between CD7 CAR\u2010T and CD19 CAR\u2010T due to their different lineage restrictions.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70201","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:32:00Z","timestamp":1760938320000},"page":"229-238","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Immune reconstitution after\n                    <scp>CD7 CAR<\/scp>\n                    \u2010T cell therapy for refractory\/relapsed acute T\u2010lymphoblastic leukaemia\/lymphoblastic lymphoma (R\/R T\u2010\n                    <scp>ALL<\/scp>\n                    \/\n                    <scp>LBL<\/scp>\n                    )"],"prefix":"10.1111","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4005-2190","authenticated-orcid":false,"given":"Xian","family":"Zhang","sequence":"first","affiliation":[{"name":"Hebei Yanda Lu Daopei Hospital  Langfang Hebei China"},{"name":"Lu Daopei Institute of Hematology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Hebei Senlang Biotechnology Co., Ltd.  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Kuang","sequence":"additional","affiliation":[{"name":"Hebei Senlang Biotechnology Co., Ltd.  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfang","family":"Yang","sequence":"additional","affiliation":[{"name":"Hebei Yanda Lu Daopei Hospital  Langfang Hebei China"},{"name":"Lu Daopei Institute of Hematology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Hebei Yanda Lu Daopei Hospital  Langfang Hebei China"},{"name":"Lu Daopei Institute of Hematology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Qiu","sequence":"additional","affiliation":[{"name":"Hebei Yanda Lu Daopei Hospital  Langfang Hebei China"},{"name":"Lu Daopei Institute of Hematology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongchu","family":"Wang","sequence":"additional","affiliation":[{"name":"Hebei Yanda Lu Daopei Hospital  Langfang Hebei China"},{"name":"Lu Daopei Institute of Hematology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Sun","sequence":"additional","affiliation":[{"name":"Hebei Senlang Biotechnology Co., Ltd.  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