{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:47:28Z","timestamp":1782280048199,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>To evaluate the efficacy and safety of the HAAV regimen (venetoclax, aclarubicin, cytarabine, homoharringtonine) as induction therapy for newly diagnosed adult acute myeloid leukaemia (AML). This multicentre, single\u2010arm, prospective clinical trial included 84 AML patients (aged 18\u201360) from eight Chinese hospitals. The HAAV regimen was administered, with venetoclax dosed at 100\u2009mg on day 1, 200\u2009mg on day 2 and 400\u2009mg on days 3\u20138, combined with homoharringtonine, cytarabine and aclarubicin on days 3\u20137. The overall response rate after one cycle was 95.2% (95% confidence interval [CI] 88.3\u201398.7), with 92.9% achieving complete remission\u2009+\u2009incomplete count recovery (95% CI 83.6\u201396.6). Among responders, 89.9% (95% CI 80.2\u201395.8) had minimal residual disease negativity. With a median follow\u2010up of 15.5\u2009months, the \u20131\u2010year overall survival was 77.9% (95% CI 18.3\u201326.1), relapse\u2010free survival was 83.9% (95% CI 19.2\u201322.3) and event\u2010free survival was 71.3% (95% CI 16.9\u201320.5). The HAAV regimen is highly efficacious and safe for newly diagnosed AML patients.<\/jats:p>","DOI":"10.1111\/bjh.70202","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T02:01:12Z","timestamp":1761703272000},"page":"189-199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Venetoclax combined with homoharringtonine, cytarabine and aclacinomycin as induction therapy in newly diagnosed Chinese acute myeloid leukaemia patients: A multicentre phase II study"],"prefix":"10.1111","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-0487","authenticated-orcid":false,"given":"Yaxian","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Hematology The Second Affiliated Hospital of Kunming Medical University  Kunming 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