{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:35:30Z","timestamp":1790804130941,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Chronic lymphocytic leukaemia (CLL) is a B\u2010cell lymphoproliferative disorder with ~40% of cases harbouring stereotyped B\u2010cell receptors (BCRs), defined by common features in their immunoglobulin sequences. Major CLL stereotypes are associated with specific genetic abnormalities that may influence prognosis. To explore their physiological counterparts, we analyzed total circulating BCR repertoires from 69 healthy volunteers (HVs) aged 18\u201378\u2009years. In healthy repertoires, mean abundances of \u2018typical\u2019 CLL\u2010like stereotyped immunoglobulins (CLS\u2010IG) and \u2018non\u2010typical\u2019 CLS\u2010IG (expected CDR3 sequences but different\n                    <jats:italic>IGHV<\/jats:italic>\n                    or\n                    <jats:italic>IGHJ<\/jats:italic>\n                    genes) were 0.053% and 0.46%, respectively, suggesting that CLL may arise from B cells expressing BCR patterns frequently shared between individuals. Stereotype distribution differed markedly from CLL cases: as an example, subset #2 was found in over 60% of HVs, while subset #1, the second most common in CLL, was absent. While typical CLS\u2010IGs were rare in HVs, they dominated in CLL. Then, we longitudinally analyzed BCR repertoires within sorted circulating B\u2010cell subpopulations in a second dataset. This revealed that the vast majority of healthy B cells carrying major CLS\u2010IGs appeared to be stuck at pre\u2010germinal centre stages. Similar to t(14;18) translocations in healthy individuals, stereotyped BCRs may lack intrinsic oncogenic potential and require additional selection events to drive CLL transformation.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70204","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:15:05Z","timestamp":1761070505000},"page":"106-115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>CLL<\/scp>\n                    \u2010like stereotyped\n                    <scp>BCRs<\/scp>\n                    are equally produced in young and old healthy adults, share features of public clonotypes and may be stuck at a pre\u2010germinal centre stage"],"prefix":"10.1111","volume":"208","author":[{"given":"Marine","family":"Dupont","sequence":"first","affiliation":[{"name":"Biological Hematology Department University Hospital Dupuytren  Limoges France"},{"name":"UMR CNRS 7276 INSERM 1262 CRIBL University of Limoges  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paco","family":"Derouault","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Biology Department University Hospital Dupuytren  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Pascal","sequence":"additional","affiliation":[{"name":"UMR CNRS 7276 INSERM 1262 CRIBL University of Limoges  Limoges France"},{"name":"Immunology and Immunogenetics Department University Hospital Dupuytren  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataliya","family":"Dmytruk","sequence":"additional","affiliation":[{"name":"Clinical Hematology and Cellular Therapy University Hospital Dupuytren  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Roubinet","sequence":"additional","affiliation":[{"name":"Biological Hematology Department University Hospital Dupuytren  Limoges France"},{"name":"UMR CNRS 7276 INSERM 1262 CRIBL University of Limoges  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Rivi\u00e8re","sequence":"additional","affiliation":[{"name":"Biological Hematology Department University Hospital Dupuytren  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mil\u00e8ne","family":"Parquet","sequence":"additional","affiliation":[{"name":"UMR CNRS 7276 INSERM 1262 CRIBL University of Limoges  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenza","family":"Guiyedi","sequence":"additional","affiliation":[{"name":"UMR CNRS 7276 INSERM 1262 CRIBL University of Limoges  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Boulin","sequence":"additional","affiliation":[{"name":"Biological Hematology Department University Hospital Dupuytren  Limoges 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