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BCL\u20102 inhibition has been a welcome addition to the treatment armamentarium for haematological malignancies. The BCL\u20102 inhibitor venetoclax is approved by the Food and Drug Administration and the European Medicines Agency for the treatment of chronic lymphocytic leukaemia and acute myeloid leukaemia and is endorsed by the National Comprehensive Cancer Network for the treatment of WM and mantle cell lymphoma. In this review, we provide an overview of the current understanding of the BCL\u20102 apoptotic pathway and its impact on the development and maintenance of haematological cancers. We also summarize the preclinical and ongoing clinical experience with BCL\u20102 inhibitors, such as venetoclax, sonrotoclax, lisaftoclax and LOXO\u2010338. BCL\u20102 inhibitors have emerged as safe and effective treatment options for treating patients with MZL and WM.<\/jats:p>","DOI":"10.1111\/bjh.70208","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T06:39:28Z","timestamp":1760942368000},"page":"2261-2269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>BCL<\/scp>\n                    \u20102 inhibition in Waldenstr\u00f6m macroglobulinaemia and marginal zone lymphoma"],"prefix":"10.1111","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0075-6735","authenticated-orcid":false,"given":"Shayna","family":"Sarosiek","sequence":"first","affiliation":[{"name":"Bing Center for Waldenstr\u00f6m Macroglobulinemia Dana\u2010Farber Cancer Institute, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uriel","family":"Suarez","sequence":"additional","affiliation":[{"name":"Department of Hematology Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Universidad Aut\u00f3noma de Madrid  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Fernandez\u2010Turizo","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Beth Israel Deaconess Medical Center, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4618-5085","authenticated-orcid":false,"given":"Kristopher A.","family":"Sarosiek","sequence":"additional","affiliation":[{"name":"John B. 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