{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T07:59:25Z","timestamp":1779263965518,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515111110"],"award-info":[{"award-number":["2022A1515111110"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    To investigate T\u2010cell glucose metabolism dysfunction in primary immune thrombocytopenia (ITP) and the role of mammalian target of rapamycin complex 1 (mTORC1) in regulatory T\u2010cell (Treg) suppression function. Gene set enrichment analysis (GSEA) assessed glycolysis and mTORC1 pathways in dysfunctional Tregs from patients with systemic lupus erythematosus (SLE). CD4\n                    <jats:sup>+<\/jats:sup>\n                    effector T cells (Teffs) were isolated from peripheral blood mononuclear cells (PBMCs) pre\u2010 and post\u2010dexamethasone treatment and from healthy controls. The extracellular acidification rate (ECAR) of Tregs and Teffs was measured using the Agilent Seahorse XF96 platform. Flow cytometry evaluated glucose transporter 1 (GLUT1) and phosphorylated S6 (p\u2010S6) expression. The immune suppression function of Tregs was assessed by mTORC1 inhibiting test. GSEA revealed a possible relation of glycolysis and mTORC1 signalling in dysfunctional Tregs. Both Tregs and Teffs from ITP patients showed elevated ECAR, with Teff ECAR normalizing post\u2010glucocorticoid treatment. Treg ECAR decreased after treatment, but remained higher than normal level. GLUT1 and p\u2010S6 expression was significantly higher in ITP Tregs and Teffs, normalizing GLUT1 levels after glucocorticoid therapy. Inhibiting mTORC1 could recover the suppression of ITP Tregs. Dysregulated CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell glucose metabolism contributes to ITP pathogenesis. Targeting mTORC1 signal may offer a novel therapeutic approach for ITP.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70229","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T14:30:38Z","timestamp":1762525838000},"page":"129-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dysfunctional T cells due to the abnormal glucose metabolism in patients with primary immune thrombocytopenia"],"prefix":"10.1111","volume":"208","author":[{"given":"Meiwen","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Hematology Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Department of Hematology The Fifth Affiliated Hospital, Sun Yat\u2010sen University  Zhuhai Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bixiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology The Fifth 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