{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T17:25:01Z","timestamp":1783704301755,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["29685"],"award-info":[{"award-number":["29685"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015570","name":"Blood Cancer UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015570","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["NIHR203331"],"award-info":[{"award-number":["NIHR203331"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    When the World Health Organization (WHO) declared the global COVID\u201019 pandemic, it was recognised that patients with haematological cancers would be more susceptible to severe disease. Set within a UK population of ~4\u2009million (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/hmrn.org\/\">https:\/\/hmrn.org\/<\/jats:ext-link>\n                    ), all patients diagnosed with haematological neoplasms 2005\u20132019 who were alive on 1 January 2020 were followed up until March 2023. For comparative purposes, a similar age\u2010 and sex\u2010matched general population cohort was also constructed. COVID\u201019 deaths were classified using ICD\u201010 codes and a multiple cause of death analysis was undertaken using a competing risk approach. Deaths of 486\/18\u2009883 haematology patients were attributed to COVID\u201019, yielding a cumulative incidence of 2.59% (95% confidence interval [CI]: 2.37\u20132.82) that was significantly higher than that of the general population (1.65; 95% CI: 1.58\u20131.72). In both cohorts, risks were higher in men, older people and those with co\u2010morbidities. Within the patient cohort, excess mortality was largely concentrated in those suffering from more indolent conditions. Patients with the premalignancy MBL suffered from the highest excess mortality in the early phase of the pandemic when, unlike patients with malignancies, they were not advised to shield. Effects of shielding were evident and a clear vaccination benefit was demonstrated, with the exception of CLL and MCL; findings that warrant consideration in relation to other viruses.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70244","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T05:45:12Z","timestamp":1762926312000},"page":"486-497","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>COVID<\/scp>\n                    \u201019\u2010related mortality in a real\u2010world cohort of 18\u2009883 patients with premalignant and malignant haematological neoplasms: An analysis from the\n                    <scp>UK<\/scp>\n                    's Haematological Malignancy Research Network"],"prefix":"10.1111","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1111-966X","authenticated-orcid":false,"given":"Alexandra","family":"Smith","sequence":"first","affiliation":[{"name":"Epidemiology &amp; Cancer Statistics Group, Department of Health Sciences Centre for Blood Research, University of York  York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1099-163X","authenticated-orcid":false,"given":"Clare","family":"Frobisher","sequence":"additional","affiliation":[{"name":"Epidemiology &amp; Cancer Statistics Group, Department of Health Sciences Centre for Blood Research, University of York  York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Varghese","sequence":"additional","affiliation":[{"name":"Department of Haematology Leeds Cancer Centre, St James's University Hospital  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0798-9790","authenticated-orcid":false,"given":"Andy","family":"Rawstron","sequence":"additional","affiliation":[{"name":"Haematological Malignancy Diagnostic Service St. James's University Hospital  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3026-2859","authenticated-orcid":false,"given":"Simon","family":"Crouch","sequence":"additional","affiliation":[{"name":"Epidemiology &amp; Cancer Statistics Group, Department of Health Sciences Centre for Blood Research, University of York  York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7521-7402","authenticated-orcid":false,"given":"Debra","family":"Howell","sequence":"additional","affiliation":[{"name":"Epidemiology &amp; Cancer Statistics Group, Department of Health Sciences Centre for Blood Research, University of York  York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adele","family":"Fielding","sequence":"additional","affiliation":[{"name":"Hull York Medical School University of York, Centre for Blood Research  York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirstine","family":"Eastick","sequence":"additional","affiliation":[{"name":"Department of Infection Hull University Teaching Hospitals NHS Trust  Hull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Cargo","sequence":"additional","affiliation":[{"name":"Haematological Malignancy Diagnostic Service St. James's University Hospital  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Burton","sequence":"additional","affiliation":[{"name":"Haematological Malignancy Diagnostic Service St. James's University Hospital  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Haematology Leeds Cancer Centre, St James's University Hospital  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Easom","sequence":"additional","affiliation":[{"name":"Department of Infection Hull University Teaching Hospitals NHS Trust  Hull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reuben","family":"Tooze","sequence":"additional","affiliation":[{"name":"Haematological Malignancy Diagnostic Service St. James's University Hospital  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Lillie","sequence":"additional","affiliation":[{"name":"Department of Infection Hull University Teaching Hospitals NHS Trust  Hull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7603-3704","authenticated-orcid":false,"given":"Eve","family":"Roman","sequence":"additional","affiliation":[{"name":"Epidemiology &amp; Cancer Statistics Group, Department of Health Sciences Centre for Blood Research, University of York  York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell","family":"Patmore","sequence":"additional","affiliation":[{"name":"Queen's Centre for Oncology and Haematology Castle Hill Hospital  Cottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-00459-7"},{"key":"e_1_2_9_3_1","unstructured":"COVID\u201019: guidance for people whose immune system means they are at higher risk. GOV.UK.https:\/\/www.gov.uk\/government\/publications\/covid\u201019\u2010guidance\u2010for\u2010people\u2010whose\u2010immune\u2010system\u2010means\u2010they\u2010are\u2010at\u2010higher\u2010risk(2024). Accessed 8 Sept 2024."},{"key":"e_1_2_9_4_1","unstructured":"Shielded Patient List.NHS England Digital.https:\/\/digital.nhs.uk\/services\/high\u2010risk\u2010shielded\u2010patients. 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GOV.UK.https:\/\/www.gov.uk\/government\/statistics\/english\u2010indices\u2010of\u2010deprivation\u20102015. Accessed 1 Sept 2024."},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyad149"},{"key":"e_1_2_9_30_1","unstructured":"World Health Organization.International Guidelines for Certification and Classification (Coding) of COVID\u201019 as Cause of Death.https:\/\/www.who.int\/publications\/m\/item\/international\u2010guidelines\u2010for\u2010certification\u2010and\u2010classification\u2010(coding)\u2010of\u2010covid\u201019\u2010as\u2010cause\u2010of\u2010death. (2020). 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