{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:08:34Z","timestamp":1773004114768,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100018592","name":"Celltrion","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Waldenstr\u00f6m's macroglobulinaemia (WM) has heterogeneous clinical features and limited standard therapeutic options. Although rituximab\u2010based combinations and Bruton's tyrosine kinase inhibitors have improved outcomes, challenges like incomplete responses and toxicity remain. This prospective, multicentre, phase II study evaluated the efficacy and safety of rituximab, bortezomib, lenalidomide and dexamethasone (R\u2010VRD) induction therapy, followed by lenalidomide maintenance in patients with symptomatic WM. Two\u2010year progression\u2010free survival (PFS) was the primary end\u2010point, and the secondary end\u2010points included overall response rate (ORR), overall survival (OS) and safety. Thirty\u2010eight patients (median age: 66\u2009years) were enrolled. The ORR was 81.6%, and 18.4% of the patients achieved a complete response (CR). The estimated 2\u2010year PFS and OS rates were 57.9% and 94.7%, respectively, after a median follow\u2010up of 38.5\u2009months. Notably, responses deepened during lenalidomide maintenance, and 16 experienced further response improvement during the maintenance phase. The most common adverse events were Grade 3\u20134 haematological toxicities, particularly neutropenia, but they were manageable. Peripheral neuropathy and rash were generally mild. Patients achieving a CR showed no disease progression within 2\u2009years, emphasizing the deep responses' prognostic value. R\u2010VRD induction, followed by lenalidomide maintenance, demonstrated high efficacy and an acceptable safety profile against symptomatic WM.<\/jats:p>","DOI":"10.1111\/bjh.70261","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T12:16:13Z","timestamp":1764332173000},"page":"545-553","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A multicentre prospective phase\n                    <scp>II<\/scp>\n                    study of rituximab combined with bortezomib, lenalidomide and dexamethasone, followed by lenalidomide maintenance (R\u2010\n                    <scp>VRD<\/scp>\n                    ) in patients with Waldenstr\u00f6m's macroglobulinaemia (\n                    <scp>KMM1803<\/scp>\n                    )"],"prefix":"10.1111","volume":"208","author":[{"given":"Sung\u2010Hoon","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Hematology\u2010Oncology Chonnam National University Hwasun Hospital, Chonnam National University Medical School  Hwasun Jeollanamdo South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dajung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kosin University College of Medicine  Busan South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Je\u2010Jung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Hematology\u2010Oncology Chonnam National University Hwasun Hospital, Chonnam National University Medical School  Hwasun Jeollanamdo South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kihyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medicine, Samsung Medical Center Sunkyunkwan University School of Medicine  Seoul South 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Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyeong Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology, Department of Internal Medicine, Institute of Health Science Gyeongsang National University Hospital, Gyeongsang National University College of Medicine  Jinju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Kyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medicine Yeungnam University College of Medicine  Daegu South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho\u2010Jin","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Pusan National University Hospital  Busan South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hallym University Sacred 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