{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:31:23Z","timestamp":1787499083286,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012232","name":"National Key Clinical Specialty Discipline Construction Program of China","doi-asserted-by":"publisher","award":["2021\u201076"],"award-info":[{"award-number":["2021\u201076"]}],"id":[{"id":"10.13039\/501100012232","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>This study provides a comprehensive assessment of haematological malignancies among children, adolescents and young adults aged 0\u201324\u2009years, using data from the Global Burden of Disease 2021 across 204 countries from 1990 to 2021. We found that global incidence and prevalence remained relatively stable, with approximately 150\u2009000 new cases and over one million prevalent cases in 2021, while mortality and disability\u2010adjusted life year (DALY) rates declined markedly. Leukaemia was the leading contributor to incidence, deaths, and DALYs, although decreases were observed across most subtypes. Age\u2010 and sex\u2010specific analyses revealed higher burdens in males and a pronounced peak in the &lt;5\u2010year group, with a secondary rise in late adolescence. High\u2010income regions bore higher incidence and DALY burdens but exhibited lower mortality, whereas low\u2013high social\u2010demographic index regions suffered disproportionate lethality and disability. These findings highlight both progress and persisting inequities, underscoring the urgent need for subtype\u2010specific interventions, earlier diagnosis and equitable treatment access to improve outcomes for young patients globally.<\/jats:p>","DOI":"10.1111\/bjh.70265","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T05:24:50Z","timestamp":1764134690000},"page":"534-544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Burden of haematological malignancies among children, adolescents and young adults: Global and high\u2010income region insights from the\n                    <scp>GBD<\/scp>\n                    2021 study"],"prefix":"10.1111","volume":"208","author":[{"given":"Shujuan","family":"Xu","sequence":"first","affiliation":[{"name":"Fujian Institute of Hematology, Fujian Province Key Laboratory on Hematology Fujian Medical University Union Hospital  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baihua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University Fujian Cancer Hospital  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Affiliated Hospital of Shandong First Medical University  Tai'an City Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenshu","family":"Xu","sequence":"additional","affiliation":[{"name":"Fujian Institute of Hematology, Fujian Province Key Laboratory on Hematology Fujian Medical University Union Hospital  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7942-1099","authenticated-orcid":false,"given":"Ping","family":"Weng","sequence":"additional","affiliation":[{"name":"Fujian Institute of Hematology, Fujian Province Key Laboratory on Hematology Fujian Medical University Union Hospital  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21871"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-023-00853-3"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.111356"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-025-05847-7"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-024-01623-9"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-07293-0"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2025.103193"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.70224"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-024-00649-y"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1542317"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2025.1527198"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0330479"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2025.115336"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-025-00684-x"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2025.1618810"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102370"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33948"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(22)00165-X"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.2128"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djae321"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-020-00908-z"},{"issue":"9","key":"e_1_2_12_23_1","first-page":"2275","article-title":"Relapsed pediatric acute myeloid leukaemia: state\u2010of\u2010the\u2010art in 2023","volume":"108","author":"Egan G","year":"2023","journal-title":"Haematologica"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16050997"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30761-7"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(23)00318-2"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30022-X"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/GO.22.00402"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw4892"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2024-066180"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-024-02452-y"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.43198"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31937"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(24)00106-6"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.29758"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30424-3"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-publhealth-032013-182354"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70265","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.70265","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70265","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:27:47Z","timestamp":1772994467000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.70265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/bjh.70265"],"URL":"https:\/\/doi.org\/10.1111\/bjh.70265","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,25]]},"assertion":[{"value":"2025-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}