{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T21:52:37Z","timestamp":1788817957765,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    In this retrospective, multicentre cohort study, we compared the real\u2010world efficacy of polatuzumab vedotin combined with rituximab, cyclophosphamide, doxorubicin and prednisone (Pola\u2010R\u2010CHP) versus the conventional rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R\u2010CHOP) in 370 patients in the propensity score matching cohort from 1096 patients with previously untreated diffuse large B\u2010cell lymphoma (DLBCL) (pola;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009185 in the matched and 356 in the full cohort). The analysis focused on clinical efficacy, the prognostic performance of established risk models and the relapse profiles with the chemotherapies. The Pola\u2010R\u2010CHP group showed superior 1\u2010year progression\u2010free survival (PFS) compared to the R\u2010CHOP group (86.7% vs. 73.5%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.027); however, the 1\u2010year overall survival (OS) was similar (92.8% vs. 89.6%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.24). Within the Pola\u2010R\u2010CHP group, the Central Nervous System International Prognostic Index (CNS\u2010IPI) effectively stratified the cumulative incidence of CNS relapse of 0%, 2.1% and 4.5% in the low, intermediate and high\u2010risk groups respectively (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.023). Additionally, the 1\u2010year incidence of nodal relapse was significantly lower in the Pola\u2010R\u2010CHP group than in the R\u2010CHOP group (2.1% vs. 10.9%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.013), whereas the incidence of extra\u2010nodal relapse remained similar (3.8% vs. 5.2%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.57). These findings underscore the clinical efficacy of Pola\u2010R\u2010CHP over R\u2010CHOP in first\u2010line DLBCL treatment. However, early extra\u2010nodal relapse and CNS relapse remained a therapeutic challenge.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70280","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T11:46:06Z","timestamp":1766749566000},"page":"554-563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy and relapse profiles of Pola\u2010R\u2010\n                    <scp>CHP<\/scp>\n                    versus R\u2010\n                    <scp>CHOP<\/scp>\n                    in previously untreated diffuse large B\u2010cell lymphoma: A multicentre real\u2010world study"],"prefix":"10.1111","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6728-3346","authenticated-orcid":false,"given":"Toshiki","family":"Terao","sequence":"first","affiliation":[{"name":"Department of Hematology, Oncology and Respiratory Medicine Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences  Okayama Japan"},{"name":"Department of Hematology Okayama University Hospital  Okayama Japan"},{"name":"Lymphoma Working Group of the Okayama Hematology Study Group (OHSG)  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Lymphoma Working Group of the Okayama Hematology Study Group (OHSG)  Okayama Japan"},{"name":"Department of Hematologic Oncology National Hospital Organization Shikoku Cancer Center  Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Lymphoma Working Group of the Okayama Hematology Study Group (OHSG)  Okayama Japan"},{"name":"Department of Hematology and Oncology Japanese Red Cross Society Himeji Hospital  Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Urata","sequence":"additional","affiliation":[{"name":"Lymphoma Working Group of the Okayama Hematology Study Group (OHSG)  Okayama Japan"},{"name":"Department of Hematology and Blood Transfusion Kochi Health Sciences Center  Kochi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuminari","family":"Fujii","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Kameda Medical Center  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Meguri","sequence":"additional","affiliation":[{"name":"Lymphoma Working Group of the Okayama Hematology Study Group (OHSG)  Okayama Japan"},{"name":"Department of Hematology Okayama City Hospital  Okayama 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Central Hospital  Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daigo","family":"Niiya","sequence":"additional","affiliation":[{"name":"Lymphoma Working Group of the Okayama Hematology Study Group (OHSG)  Okayama Japan"},{"name":"Department of Hematology Japanese Red Cross Okayama Hospital  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Asakura","sequence":"additional","affiliation":[{"name":"Lymphoma Working Group of the Okayama Hematology Study Group (OHSG)  Okayama Japan"},{"name":"Department of Internal Medicine Okayama Rosai Hospital  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisakazu","family":"Nishimori","sequence":"additional","affiliation":[{"name":"Lymphoma Working Group of the Okayama Hematology Study Group (OHSG)  Okayama Japan"},{"name":"Department of Hematology Hiroshima City Hiroshima Citizens Hospital  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7398-4616","authenticated-orcid":false,"given":"Daisuke","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Hematology Okayama University Hospital  Okayama Japan"},{"name":"Lymphoma Working Group of the Okayama Hematology Study Group (OHSG)  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Hematology Okayama University Hospital  Okayama Japan"},{"name":"Lymphoma Working Group of the Okayama Hematology Study Group (OHSG)  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Ennishi","sequence":"additional","affiliation":[{"name":"Lymphoma Working Group of the Okayama Hematology Study Group (OHSG)  Okayama Japan"},{"name":"Center for Comprehensive Genomic Medicine Okayama University Hospital  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