{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T05:49:50Z","timestamp":1782107390437,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    B\u2010cell acute lymphoblastic leukaemia (B\u2010ALL) in adolescents and adults remains challenging due to high relapse rates and suboptimal outcomes. Although minimal residual disease (MRD) and cytogenetic risk classification are independent prognostic indicators for B\u2010ALL in adolescents and adults, their combined utility remains under explored. This retrospective study analysed 609 adolescent and adult patients with B\u2010ALL to evaluate the integrated prognostic value of MRD at end of induction (MRD1) and after first consolidation (MRD2), combined with cytogenetic risk stratification (standard risk [SR] vs. poor risk [PR]). Although cytogenetic risk alone was not an independent prognostic factor, MRD positivity at either time point significantly predicted inferior 5\u2010year RFS and OS in PR patients. Allogeneic haematopoietic stem cell transplantation (allo\u2010HSCT) improved outcomes overall; however, PR patients with MRD2 positivity remained at high risk of relapse post\u2010transplant. Multivariate analysis identified MRD1 and MRD2 as independent predictors of both relapse (RFS HR\u2009=\u20092.048) and mortality (OS HR\u2009=\u20091.979) in PR patients (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). These results demonstrate that combining MRD assessment with cytogenetic risk improves risk stratification, precisely identifying poor\u2010risk patients with persistent MRD who may benefit from treatment intensification, including novel strategies post\u2010transplant.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70281","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:23:31Z","timestamp":1765599811000},"page":"954-964","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated prognostic value of\n                    <scp>MRD<\/scp>\n                    and cytogenetics in adolescent and adult B\u2010cell acute lymphoblastic leukaemia"],"prefix":"10.1111","volume":"208","author":[{"given":"Jiayan","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital, College of Medicine, Institute of Hematology Zhejiang University  Hangzhou China"},{"name":"Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment  Hangzhou Zhejiang China"},{"name":"Zhejiang Provincial Clinical Research Center for Hematological Disorders  Hangzhou China"},{"name":"Zhejiang University Cancer Center Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital, College of Medicine, Institute of Hematology Zhejiang University  Hangzhou China"},{"name":"Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment  Hangzhou Zhejiang China"},{"name":"Zhejiang Provincial Clinical Research Center for Hematological Disorders  Hangzhou China"},{"name":"Zhejiang University Cancer Center Zhejiang University  Hangzhou 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Provincial Clinical Research Center for Hematological Disorders  Hangzhou China"},{"name":"Zhejiang University Cancer Center Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8166-9915","authenticated-orcid":false,"given":"Jie","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital, College of Medicine, Institute of Hematology Zhejiang University  Hangzhou China"},{"name":"Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment  Hangzhou Zhejiang China"},{"name":"Zhejiang Provincial Clinical Research Center for Hematological Disorders  Hangzhou China"},{"name":"Zhejiang University Cancer Center Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5603-4160","authenticated-orcid":false,"given":"Hongyan","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital, College of Medicine, Institute of Hematology Zhejiang University  Hangzhou China"},{"name":"Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment  Hangzhou Zhejiang China"},{"name":"Zhejiang Provincial Clinical Research Center for Hematological Disorders  Hangzhou China"},{"name":"Zhejiang University Cancer Center Zhejiang University  Hangzhou 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