{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:39Z","timestamp":1787013939536,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370195"],"award-info":[{"award-number":["82370195"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200151"],"award-info":[{"award-number":["82200151"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20231367"],"award-info":[{"award-number":["BK20231367"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Myelodysplastic syndromes (MDS) are heterogeneous stem cell disorders with a 30%\u201340% risk of transformation to acute myeloid leukaemia (AML). This study characterised the genetic and clinicopathological features of 437 newly diagnosed MDS patients. A predictive model for AML transformation was developed, which identified the bone marrow blast percentage,\n                    <jats:italic>KRAS<\/jats:italic>\n                    ,\n                    <jats:italic>STAG2<\/jats:italic>\n                    and\n                    <jats:italic>TP53<\/jats:italic>\n                    mutations as significant predictors of disease progression. Novel prognostic models for overall survival (OS) and progression\u2010free survival (PFS) were established and validated. The OS model incorporated age, sex and mutations in\n                    <jats:italic>TP53<\/jats:italic>\n                    ,\n                    <jats:italic>NF1<\/jats:italic>\n                    ,\n                    <jats:italic>SRSF2<\/jats:italic>\n                    ,\n                    <jats:italic>CSF3R<\/jats:italic>\n                    ,\n                    <jats:italic>ETV6<\/jats:italic>\n                    ,\n                    <jats:italic>CEBPA<\/jats:italic>\n                    ,\n                    <jats:italic>BCOR<\/jats:italic>\n                    ,\n                    <jats:italic>TET2<\/jats:italic>\n                    ,\n                    <jats:italic>JAK2<\/jats:italic>\n                    and\n                    <jats:italic>SF3B1<\/jats:italic>\n                    . The PFS model incorporated age, sex, bone marrow blast percentage and mutations in\n                    <jats:italic>STAT3<\/jats:italic>\n                    ,\n                    <jats:italic>TP53<\/jats:italic>\n                    ,\n                    <jats:italic>NF1<\/jats:italic>\n                    ,\n                    <jats:italic>CEBPA<\/jats:italic>\n                    ,\n                    <jats:italic>ETV6<\/jats:italic>\n                    ,\n                    <jats:italic>CALR<\/jats:italic>\n                    ,\n                    <jats:italic>DNMT3A<\/jats:italic>\n                    ,\n                    <jats:italic>IDH2<\/jats:italic>\n                    ,\n                    <jats:italic>GATA2<\/jats:italic>\n                    ,\n                    <jats:italic>BCOR<\/jats:italic>\n                    ,\n                    <jats:italic>JAK2<\/jats:italic>\n                    ,\n                    <jats:italic>TET2<\/jats:italic>\n                    and\n                    <jats:italic>SF3B1<\/jats:italic>\n                    . These models stratify patients into favourable, intermediate\u20101, intermediate\u20102 and adverse risk groups, demonstrating superior risk stratification compared to the Revised\/Molecular International Prognostic Scoring System (IPSS\u2010R\/M). This work provides the first genomic characterisation of a diagnosed MDS cohort in China and establishes the first risk prediction model for MDS\u2010to\u2010AML transformation, alongside novel prognostic models for OS and PFS. These tools offer improved prognostic prediction and potential guidance for therapeutic strategies in Chinese patients with MDS.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70284","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:26:28Z","timestamp":1765585588000},"page":"524-533","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Integration of genomic and clinical variables improves the prediction of myelodysplastic syndromes to acute myeloid leukaemia transformation and prognosis"],"prefix":"10.1111","volume":"208","author":[{"given":"Huimin","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing China"},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing China"},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing China"},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing China"},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing China"},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hairong","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing China"},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing China"},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1873-6462","authenticated-orcid":false,"given":"Yuemin","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing China"},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3944-5897","authenticated-orcid":false,"given":"Guangsheng","family":"He","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing China"},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9368-4987","authenticated-orcid":false,"given":"Lei","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing China"},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4000-8210","authenticated-orcid":false,"given":"Zhongxun","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing China"},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing China"},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"},{"name":"Key Laboratory of Hematology of Nanjing Medical University  Nanjing China"},{"name":"Collaborative Innovation Center for Cancer Personalized Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-022-00402-5"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2021.07.031"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.14578"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2023.102673"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2022.215691"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-04-522136"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-019-0158-5"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.336"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.138"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-03-420489"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.01784"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25234"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26984"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.70078"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403688"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01613-1"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25950"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-01-0040"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2909"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13030481"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-9967-2_13"},{"issue":"2","key":"e_1_2_11_23_1","first-page":"338","article-title":"p53 expression in myeloid cells of myelodysplastic syndromes. Association with evolution of overt leukemia","volume":"145","author":"Kitagawa M","year":"1994","journal-title":"Am J Pathol"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.31.8576"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2023.101055"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.33.4938"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03084-7"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019004259"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-024-02347-y"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.142149"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3742"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-020-02500-y"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1013343"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-018-2627-3"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.01659"},{"issue":"9","key":"e_1_2_11_36_1","article-title":"Health\u2010related quality of life profile of newly diagnosed patients with myelodysplastic syndromes by age, sex, and risk group: a real\u2010world study by the GIMEMA","volume":"7","author":"Efficace F","year":"2023","journal-title":"Hema"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24606"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70284","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.70284","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:27:19Z","timestamp":1772994439000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.70284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,12]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/bjh.70284"],"URL":"https:\/\/doi.org\/10.1111\/bjh.70284","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,12]]},"assertion":[{"value":"2025-08-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}