{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T05:49:50Z","timestamp":1782107390467,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Central nervous system (CNS) involvement is a known complication of adult T\u2010cell leukaemia\/lymphoma (ATL), but its clinical characteristics and incidence still remain unclear. This study characterized the clinical features and incidence of CNS involvement in patients with ATL (CNS\u2010ATL). Overall, 213 patients diagnosed with aggressive ATL were retrospectively analysed at the Kagoshima University Hospital between 2002 and 2021. Of which, 28 (13.1%) developed CNS\u2010ATL. Patients with CNS\u2010ATL observed at ATL diagnosis were classified as acute (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200921, 75%), lymphoma (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091, 3.6%) or chronic (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20095, 17.9%); CNS\u2010ATL observed post\u2010ATL diagnosis comprised 10.2% (10\/98) acute, 1.8% (1\/54) lymphoma and 16.1% (5\/31) chronic cases. Of the 28 patients, 11 (39.3%) had asymptomatic meningeal involvement detected at prophylactic intrathecal therapy, 10 (35.7%) exhibited neurological symptoms at ATL diagnosis, 4 developed symptomatic CNS involvement during induction therapy and 3 experienced CNS relapse post\u2010treatment. Two\u2010year overall survival of CNS\u2010ATL was significantly lower than that of non\u2010CNS\u2010ATL, whereas 1\u2010year cumulative incidence of CNS involvement post\u2010ATL diagnosis was 12.3%. In conclusion, CNS involvement in ATL tends to occur early in the disease course and is associated with a poor prognosis, with a tendency for a higher incidence in acute\u2010type than in lymphoma\u2010type ATL.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70301","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:55:06Z","timestamp":1767678906000},"page":"947-953","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical features and incidence of central nervous system involvement in patients with adult T\u2010cell leukaemia\/lymphoma"],"prefix":"10.1111","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6927-5581","authenticated-orcid":false,"given":"Takuya","family":"Ueno","sequence":"first","affiliation":[{"name":"Department of Hematology and Rheumatology Kagoshima University Hospital  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Yoshimitsu","sequence":"additional","affiliation":[{"name":"Department of Hematology and Rheumatology Kagoshima University Hospital  Kagoshima Japan"},{"name":"Department of Hematology and Rheumatology, Graduate School of Medical and Dental Sciences Kagoshima University  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momone","family":"Sameshima","sequence":"additional","affiliation":[{"name":"Department of Hematology and Rheumatology Kagoshima University Hospital  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taichi","family":"Nagano","sequence":"additional","affiliation":[{"name":"Department of Hematology and Rheumatology Kagoshima University Hospital  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rika","family":"Akahoshi","sequence":"additional","affiliation":[{"name":"Department of Hematology 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