{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T15:46:37Z","timestamp":1773416797434,"version":"3.50.1"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T00:00:00Z","timestamp":1766620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T00:00:00Z","timestamp":1766620800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000014","name":"Canadian Blood Services","doi-asserted-by":"publisher","award":["KFA2022\u2010JC"],"award-info":[{"award-number":["KFA2022\u2010JC"]}],"id":[{"id":"10.13039\/501100000014","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Despite evidence\u2010based guidelines to inform platelet transfusion practice, unnecessary platelet transfusion persists. We performed a multicentre retrospective analysis of adults admitted to general medicine, subspecialty medicine and critical care from 1 January 2017 to 30 June 2022. Platelet transfusion guideline compliance was defined as platelet transfusion below 100\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L for neurosurgical, cardiac surgery or extracorporeal membrane oxygenation indications, below 50\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L for invasive procedures, bleeding or therapeutic anticoagulation, and below 10\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L if the patient did not have an immune\u2010mediated thrombocytopenia. We analysed 821\u2009950 patient admissions at 22 hospital sites, identifying 56\u2009825 platelet transfusion events. Overall, 13\u2009199 (23.2%) platelet transfusion events were guideline\u2010non\u2010compliant. High rates of non\u2010compliant transfusions were observed in the context of anti\u2010platelet therapy (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091515, 48.5% non\u2010compliant), cardiac surgery (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091935, 49.7%), invasive procedures (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20094648, 29.2%), immune\u2010mediated thrombocytopenia (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009596, 32.9%) and primary prophylaxis (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20097370, 47.2%). After adjusting for physician characteristics, there was a lower risk of guideline\u2010non\u2010compliant platelet transfusions at academic than at community hospitals (odds ratio [OR] 0.768, 95% confidence interval [CI] 0.678\u20130.871,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Physician specialty, but not physician gender or years in practice, influenced guideline compliance. These findings underscore the need for targeted intervention to optimize platelet transfusion practices, minimize avoidable transfusion reactions, reduce costs and mitigate platelet shortages.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70304","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T06:01:06Z","timestamp":1766728866000},"page":"670-682","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Opportunities for improving platelet transfusion practice: A large retrospective audit across 22 hospitals"],"prefix":"10.1111","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3085-9636","authenticated-orcid":false,"given":"Sarah","family":"Ryan","sequence":"first","affiliation":[{"name":"Department of Medicine Queen's University  Kingston Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medicine McMaster University  Hamilton Ontario Canada"},{"name":"Michael G. DeGroote Centre for Transfusion Research McMaster University  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8247-1484","authenticated-orcid":false,"given":"Sheharyar","family":"Raza","sequence":"additional","affiliation":[{"name":"Medical Affairs and Innovation Canadian Blood Services  Toronto Ontario Canada"},{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Loeffler","sequence":"additional","affiliation":[{"name":"Li Ka Shing Knowledge Institute St.\u00a0Michael's Hospital, Unity Health Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Relke","sequence":"additional","affiliation":[{"name":"Medical Affairs and Innovation Canadian Blood Services  Toronto Ontario Canada"},{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Gabarin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"},{"name":"University Health Network  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm","family":"Risk","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phuong Uyen","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Community Health Sciences, Cumming School of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[{"name":"Michael G. 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