{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T05:49:49Z","timestamp":1782107389021,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>The efficacy of a triple combination of rabbit anti\u2010human thymocyte immunoglobulin (rATG), ciclosporin and eltrombopag (EPAG) was prospectively evaluated in patients with severe or transfusion\u2010dependent non\u2010severe aplastic anaemia (SAA) across 29 institutions in Japan. Sixty patients were enrolled, of whom 48 had SAA. The primary end\u2010point, the haematological overall response rate at 12\u2009weeks, was 52.6% (95% confidence interval, 39.0%\u201366.0%), increasing to 67.9% at 26\u2009weeks. The most frequent grade 3\/4 adverse event was febrile neutropenia (20.0%). One elderly patient with severe neutropenia died of sepsis. Progression to myelodysplastic syndrome (MDS) or acute myeloid leukaemia (AML) was observed in one patient each. There was no association between the haematological response and high thrombopoietin levels, presence of paroxysmal nocturnal haemoglobinuria\u2010type cells or Human Leukocyte Antigen (HLA)\u00a0class I allele\u2010lacking cells. Five patients (8.5%) had chromosomal abnormalities at baseline with no subsequent progression to MDS or AML. By 26\u2009weeks, chromosomal abnormalities had emerged or expanded in eight patients (17.4%), although abnormalities of chromosome 7 were not observed within 52\u2009weeks. These results suggest that triple therapy with rATG may be as effective as that with horse anti\u2010human thymocyte immunoglobulin. Notably, the addition of EPAG did not induce chromosomal abnormalities associated with poor prognosis.<\/jats:p>","DOI":"10.1111\/bjh.70307","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:34:16Z","timestamp":1767573256000},"page":"1084-1092","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phase\n                    <scp>II<\/scp>\n                    study of the triple combination of rabbit\n                    <scp>ATG<\/scp>\n                    , ciclosporin and eltrombopag in patients with transfusion\u2010dependent aplastic anaemia: West Japan Hematology Study Group (W\u2010\n                    <scp>JHS<\/scp>\n                    )\n                    <scp>AA02<\/scp>\n                    trial"],"prefix":"10.1111","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8554-1864","authenticated-orcid":false,"given":"Fumi","family":"Nakamura","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology Dokkyo Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6189-0620","authenticated-orcid":false,"given":"Ken","family":"Ishiyama","sequence":"additional","affiliation":[{"name":"Department of Hematology National Center for Global Health and Medicine  Tokyo Japan"},{"name":"Department of Hematology Kanazawa University Hospital  Kanazawa Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5974-7614","authenticated-orcid":false,"given":"Ritsuro","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Internal Medicine Faculty of Medicine, Shimane 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University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7778-5374","authenticated-orcid":false,"given":"Seishi","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Pathology and Tumor Biology Kyoto University  Kyoto Japan"},{"name":"Institute for the Advanced Study of Human Biology (WPI\u2010ASHBi), Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kana","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmaceutics Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts  Kyotanabe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8296-6412","authenticated-orcid":false,"given":"Takuto","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber\/Boston Children's Cancer and Blood Disorders Center  Boston 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