{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T13:08:21Z","timestamp":1778936901366,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Venous thromboembolism (VTE) is a common cause of morbidity and mortality in sickle cell disease (SCD). The aim of the study was to review the safety and effectiveness of primary and secondary anti\u2010coagulation prophylaxis in hospitalized SCD patient population and to identify potential VTE risk factors. Retrospective review of prescribed anti\u2010coagulants in hospitalized SCD patients from 1 January 2015 to 11 July 2023. Pharmacological prophylaxis was provided to those \u226513\u2009years of age. Bleeding and thrombosis outcomes were classified as per the International Society Thrombosis and Haemostasis. Generalized logistic mixed models with a random intercept for each patient were used to assess VTE risk. Seven hundred and ninety hospital encounters among 140 unique patients were reviewed. Median age at admission: 17.2\u2009years (interquartile range [IQR]: 13.9\u201319.0). Primary and secondary prophylactic anti\u2010coagulation was prescribed in 81.0% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009640) and 18.4% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009146) hospital encounters respectively. Thirty VTE events were identified among 22 individuals (3.8%;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200930\/790). Seven VTE recurrences\/progression (23.3%) occurred. Surgical splenectomy was significantly associated with VTE (53.3%;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200916\/30) versus those without VTE (23.3%;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009177\/760) (odds ratio 4.23, 95% confidence interval [CI] 1.36\u201313.15;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0128). Despite the use of pharmacological VTE prophylaxis, 30 VTE events with a thrombosis recurrence\/progression rate of 23.3% occurred. Further studies are needed to guide pharmacological prophylaxis for those at greater thrombosis risk.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70311","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T04:15:43Z","timestamp":1767672943000},"page":"1380-1388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Safety and efficacy of anti\u2010coagulation for primary and secondary venous thromboembolism prophylaxis in hospitalized adolescents and young adults with sickle cell disease: An institutional experience"],"prefix":"10.1111","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0990-544X","authenticated-orcid":false,"given":"Vilmarie","family":"Rodriguez","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology\u2010Oncology and Bone Marrow Transplantation Nationwide Childrens' Hospital  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Sankar","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\u2010Oncology and Bone Marrow Transplantation Nationwide Childrens' Hospital  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Stanek","sequence":"additional","affiliation":[{"name":"Biostatistics Resource at Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassandra","family":"Rush","sequence":"additional","affiliation":[{"name":"Advanced Patient Care Pharmacist, Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Villella","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\u2010Oncology and Bone Marrow Transplantation Nationwide Childrens' Hospital  Columbus Ohio 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