{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:03:30Z","timestamp":1791583410003,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    In adults with classic Hodgkin lymphoma (cHL), metabolic tumour volume (MTV) is valuable for risk stratification. This systematic review explored the role of volumetric parameters in children, adolescents and young adults (CAYA) with cHL. This systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses (PRISMA) method. Five databases were searched on 16 October 2024. Eligible studies were peer\u2010reviewed manuscripts, written in English, published since database inception that included patients \u226421\u2009years of age with a diagnosis of cHL treated with chemotherapy \u00b1 radiotherapy with a baseline\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010Fluorodeoxyglucose (F\u2010FDG) PET\/CT scan for MTV quantification. The search strategy identified 3669 studies, of which 35 were eligible for inclusion. Fifteen studies (43%) evaluated a cohort exclusively \u226421\u2009years of age. All eight studies that explored the association of baseline PET parameters with known risk factors identified a significant correlation. Nine of 12 papers (75%) demonstrated a statistically significant correlation with disease response to therapy on PET\/CT. Fifteen of 20 papers (75%) demonstrated an independent statistically significant correlation with clinical outcomes. In the CAYAHL population, volumetric PET parameters are valuable for risk stratification despite heterogeneity in results. Future harmonization of the segmentation approach will facilitate incorporation of MTV into clinical practice.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70329","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T02:44:37Z","timestamp":1768445077000},"page":"1185-1195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic role of\n                    <scp>PET<\/scp>\n                    \/\n                    <scp>CT<\/scp>\n                    volumetric parameters in paediatric Hodgkin lymphoma: A systematic review and expert recommendations from the International\n                    <scp>SEARCH<\/scp>\n                    for\n                    <scp>CAYAHL<\/scp>\n                    Group"],"prefix":"10.1111","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8054-0635","authenticated-orcid":false,"given":"S. Claire","family":"Gowdy","sequence":"first","affiliation":[{"name":"Department of Radiology BC Children's Hospital and the University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4182-9355","authenticated-orcid":false,"given":"Jamie E.","family":"Flerlage","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology, Department of Pediatrics University of Rochester Medical Center  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Seelisch","sequence":"additional","affiliation":[{"name":"Children's Hospital London Health Sciences Centre, Department of Pediatrics Western University  London Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Palese","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology, Department of Pediatrics University of Rochester Medical Center  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Bradshaw","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Wisconsin\u2013Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon M.","family":"Castellino","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Emory University School of Medicine and Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Dieckmann","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2312-5418","authenticated-orcid":false,"given":"Bradford S.","family":"Hoppe","sequence":"additional","affiliation":[{"name":"Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Howard","sequence":"additional","affiliation":[{"name":"University of Tennessee Health Science Center  Memphis USA"},{"name":"Resonance, Inc.  Arlington Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara M.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Roswell Park Comprehensive Cancer Center, University at Buffalo Jacobs School of Medicine and Biomedical Sciences  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Kurch","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hollie A.","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Radiology Children's Health of Orange County  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egesta","family":"Lopci","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, IRCCS\u2010Humanitas Research Hospital  Rozzano Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"John T.","family":"Lucas","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Mauz\u2010K\u00f6rholz","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology Justus\u2010Liebig\u2010University of Giessen  Giessen Germany"},{"name":"Medical Faculty of the Martin\u2010Luther University of Halle\u2010Wittenberg  Halle Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"McCarten","sequence":"additional","affiliation":[{"name":"Quality Assurance Review Center (QARC)\/Imaging and Radiation Oncology Core Group (IROC)  Lincoln Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeta","family":"Pandit\u2010Taskar","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Sch\u00f6der","sequence":"additional","affiliation":[{"name":"Molecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Steglich","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology Heart Center Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5105-4488","authenticated-orcid":false,"given":"Dietrich","family":"Stoevesandt","sequence":"additional","affiliation":[{"name":"Department of Radiology University Hospital Halle (Saale)  Halle (Saale) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan D.","family":"Voss","sequence":"additional","affiliation":[{"name":"Department of Radiology Boston Children's Hospital, Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Milgrom","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Colorado  Aurora USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102015\u201011\u2010679407"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2018.11.018"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012643.pub3"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1510093"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.63.1119"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.75.2543"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00947"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12282"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.210047"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102017\u201007\u2010795476"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102017\u201004\u2010773838"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010014\u20102783\u2010x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102017\u201006\u2010788877"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.205633"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers7010287"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11206223"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2023.2238125"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.29212"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18734"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10245979"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0000000000001337"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010018\u20104432\u20104"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12149\u2010011\u20100539\u20102"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.4274\/mirt.94914"},{"key":"e_1_2_11_27_1","doi-asserted-by":"crossref","unstructured":"TieX ShinM LeeC PerlmanSB HuemannZ WeismanAJ et\u00a0al.Automatic quantification of serial PET\/CT images for pediatric Hodgkin lymphoma patients using a longitudinally\u2010aware segmentation network.ArXiv. arXiv:2404.08611v2.2024.https:\/\/doi.org\/10.48550\/arXiv.2404.08611","DOI":"10.1148\/ryai.240229"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40658\u2010020\u201000346\u20103"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010024\u201006643\u20108"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/1754\u20109485.12993"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.2298\/VSP160322087A"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201037197\u2010z"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201069577\u20109"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021005385"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43055\u2010021\u201000670\u20103"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnmt.119.231118"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010022\u201009039\u20100"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10194396"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201047453\u20105"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140830"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000002732"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010014\u20102705\u2010y"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpf.12868"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010023\u201005461\u20106"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748\u2010717X\u20107\u20105"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6347404"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.HS9.0000890652.56016.97"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.119.227249"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.124.267789"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.124.267789"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.124.269271"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70329","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.70329","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70329","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T12:30:31Z","timestamp":1778934631000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.70329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,14]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/bjh.70329"],"URL":"https:\/\/doi.org\/10.1111\/bjh.70329","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,14]]},"assertion":[{"value":"2025-09-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}