{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T05:49:40Z","timestamp":1782107380107,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Small nucleolar ribonucleic acids (snoRNAs) are a class of small non\u2010coding RNAs involved in the post\u2010transcriptional modification of ribosomal RNAs (rRNA) and small nuclear RNAs (snRNA). Mounting evidence indicates that specific snoRNAs are drivers of oncogenesis, but their role in B\u2010cell precursor acute lymphoblastic leukaemia (BCP\u2010ALL) is unknown. We found that a small subset of 30 snoRNAs is commonly deregulated in BCP\u2010ALL. Small Cajal body\u2010specific RNA 12 (scaRNA12) was the strongest downregulated snoRNAs in BCP\u2010ALL. Forced expression of scaRNA12 in BCP\u2010ALL cells largely recovered the level of uridine\u201046 pseudouridylation of U5 snRNA (U5:\u03a846), an important RNA modification for proper splicing and gene expression regulation. We found that scaRNA12 controls a set of genes that belong to pathways that are frequently affected in BCP\u2010ALL samples. We show that scaRNA12 activates p53, which is commonly affected in BCP\u2010ALL even in the absence of p53 mutations. We show that scaRNA12 expression decreased the expression of upstream p53 regulators and provide novel evidence for a role of scaRNA12 in p53 regulation. We found that forced expression of scaRNA12 in BCP\u2010ALL increased p53 activity and significantly enhanced the sensitivity of BCP\u2010ALL to chemotherapeutic reagents. Together, our results suggest a tumour\u2010suppressing role for scaRNA12 in BCP\u2010ALL.<\/jats:p>","DOI":"10.1111\/bjh.70336","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T10:46:15Z","timestamp":1768819575000},"page":"883-896","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The impact of\n                    <scp>scaRNA12<\/scp>\n                    deregulation on p53\u2010mediated cellular stress response in B\u2010cell precursor acute lymphoblastic leukaemia"],"prefix":"10.1111","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7240-5176","authenticated-orcid":false,"given":"Martijn W. 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