{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:32:06Z","timestamp":1787502726851,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"Summary<\/jats:title>\n \n Waldenstr\u00f6m's macroglobulinaemia (\n WM<\/jats:styled-content>\n ) is a rare B\u2010cell lymphoproliferative disorder with multiple effective front\u2010line treatment options. However, real\u2010world comparative data on commonly used regimens are limited. We conducted a retrospective cohort study of 348 consecutive, newly diagnosed\n WM<\/jats:styled-content>\n patients treated between 2002 and 2024. Patients received first\u2010line therapy with either bortezomib\u2013dexamethasone\u2013rituximab (\n BDR<\/jats:styled-content>\n ,\n n<\/jats:italic>\n \u2009=\u200935), Bruton's tyrosine kinase inhibitors (\n BTKis<\/jats:styled-content>\n ,\n n<\/jats:italic>\n \u2009=\u200957) or dexamethasone\u2013rituximab\u2013cyclophosphamide (\n DRC<\/jats:styled-content>\n ,\n n<\/jats:italic>\n \u2009=\u2009256).\n BTKi<\/jats:styled-content>\n demonstrated the highest\n MRR<\/jats:styled-content>\n (major response rate, \u2265\n PR<\/jats:styled-content>\n ) (80.7%), followed by\n DRC<\/jats:styled-content>\n (68.4%) and\n BDR<\/jats:styled-content>\n (40.0%) (\n p<\/jats:italic>\n \u2009<\u20090.001). The median\n PFS<\/jats:styled-content>\n and\n OS<\/jats:styled-content>\n did not differ significantly among regimens.\n TTNT<\/jats:styled-content>\n seemed to be longer in the\n BTKi<\/jats:styled-content>\n group (log\u2010rank\n p<\/jats:italic>\n \u2009=\u20090.025), with a 74% reduced risk of salvage therapy compared to\n DRC<\/jats:styled-content>\n (\n aHR<\/jats:styled-content>\n \u2009=\u20090.26,\n p<\/jats:italic>\n \u2009=\u20090.016). Cumulative\n WM<\/jats:styled-content>\n \u2010related mortality at 5\u2009years was lowest in\n BTKi<\/jats:styled-content>\n \u2010treated patients (4.1% vs. 13.0%\n DRC<\/jats:styled-content>\n vs. 17.1%\n BDR<\/jats:styled-content>\n ), though differences were not statistically significant. In this single\u2010centre analysis, both\n BTKi<\/jats:styled-content>\n and\n DRC<\/jats:styled-content>\n led to prolonged disease control in the upfront treatment of patients with\n WM<\/jats:styled-content>\n . Extended follow\u2010up and prospective validation are needed to reveal potential long\u2010term survival differences.\n <\/jats:p>","DOI":"10.1111\/bjh.70342","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T04:40:01Z","timestamp":1769143201000},"page":"937-946","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical outcomes in newly diagnosed patients with Waldenstr\u00f6m's macroglobulinaemia treated in a tertiary academic centre"],"prefix":"10.1111","volume":"208","author":[{"given":"Maria","family":"Gavriatopoulou","sequence":"first","affiliation":[{"name":"Department of Clinical Therapeutics National and Kapodistrian University of Athens, School of Medicine Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6328-9783","authenticated-orcid":false,"given":"Ioannis","family":"Ntanasis\u2010Stathopoulos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics National and Kapodistrian University of Athens, School of Medicine Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Malandrakis","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics National and Kapodistrian University of Athens, School of Medicine Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charalampos","family":"Filippatos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics National and Kapodistrian University of Athens, School of Medicine Athens 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Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Kanellias","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics National and Kapodistrian University of Athens, School of Medicine Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Eleutherakis\u2010Papaiakovou","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics National and Kapodistrian University of Athens, School of Medicine Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0618-8900","authenticated-orcid":false,"given":"Despina","family":"Fotiou","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics National and Kapodistrian University of Athens, School of Medicine Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9404-807X","authenticated-orcid":false,"given":"Eirini","family":"Katodritou","sequence":"additional","affiliation":[{"name":"Department of Hematology Theagenio Cancer Hospital Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanouil","family":"Spanoudakis","sequence":"additional","affiliation":[{"name":"Department of Hematology University of Thrace, School of Medicine Alexandroupolis Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Tsirigotis","sequence":"additional","affiliation":[{"name":"BMT Unit, Department of Internal Medicine Attikon University Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Giannakoulas","sequence":"additional","affiliation":[{"name":"Department of Hematology University of Thessaly, University Hospital of Larissa 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