{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:42:11Z","timestamp":1788176531270,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Bridging therapy (BT) prior to brexucabtagene autoleucel (brexu\u2010cel) in mantle cell lymphoma (MCL) is supported by limited evidence. Here, we report BT modality and outcome in 176 patients at 15 centres in the United Kingdom. BT was delivered to 90% (158\/176), the majority receiving standard chemotherapy +\/\u2212 radiotherapy (53%) (SD chemo +\/\u2212 RT) or targeted therapy (TT) alone (23%). Clinicians favoured SD chemo +\/\u2212 RT in those with Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 1, blastoid disease, bulk &gt;5\u2009cm and elevated lactate dehydrogenase. Overall response rate (ORR) was 46%. Higher ORR was observed with SD chemo +\/\u2212 RT (58%), particularly R\u2010BAC (64%). Progressive disease despite BT was associated with a lower ORR to brexu\u2010cel (77% vs. 91%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03) and a higher risk of \u2265grade 3 ICANS (OR 3.43, 95% CI 1.44\u20138.10,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01). SD chemo +\/\u2212 RT was associated with a higher incidence of \u2265grade 3 neutropenia (Month 1), \u2265grade 3 thrombocytopenia (Month 1, Month 3) and early non\u2010relapse mortality (&lt;90\u2009days, 13% vs. 0%) compared to TT alone. Neither BT modality nor response impacted progression\u2010free or overall survival post\u2010infusion. Review of haematopoietic reserve prior to the selection of BT regimen, rigorous management of delayed cytopenia post\u2010infusion and more effective and tolerable BT should be prioritised.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70357","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T02:00:50Z","timestamp":1773021650000},"page":"1347-1358","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bridging practices prior to brexucabtagene autoleucel for mantle cell lymphoma in the United Kingdom: An analysis of modality, response, toxicity and survival"],"prefix":"10.1111","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2702-397X","authenticated-orcid":false,"given":"Maeve A.","family":"O'Reilly","sequence":"first","affiliation":[{"name":"Department of Haematology University College London Hospital  London UK"},{"name":"Department of Haematology University College London Cancer Institute  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Wilson","sequence":"additional","affiliation":[{"name":"Cancer Research UK and University College London Cancer Trials Centre  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Maybury","sequence":"additional","affiliation":[{"name":"Department of Haematology University Hospital Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4952-2550","authenticated-orcid":false,"given":"Andrea","family":"Kuhnl","sequence":"additional","affiliation":[{"name":"Department of Haematology Kings College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Roddie","sequence":"additional","affiliation":[{"name":"Department of Haematology University College London Hospital  London UK"},{"name":"Department of 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