{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:23:19Z","timestamp":1791314599680,"version":"4.3.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Despite the improvement in outcomes of patients with newly diagnosed multiple myeloma (NDMM) with quadruplet therapy (QUAD) and autologous stem cell transplantation (ASCT), outcomes are heterogeneous. The International Myeloma Society (IMS) and International Myeloma Working Group (IMWG) published new consensus high\u2010risk (new\u2010HiR) criteria which combine cytogenetic abnormalities, next\u2010generation sequencing data, \u03b22 microglobulin and renal function developed in a population treated prior to the introduction of QUADs. We utilized a cohort of NDMM patients treated with QUAD\u2009+\u2009ASCT with a median follow\u2010up of 41.5\u2009months to validate the IMS\/IMWG high\u2010risk criteria and compared the performance of the old\u2010HiR, based on the presence of t(4;14), t(14;16) or del(17p) versus new\u2010HiR criteria. Among the 310 patients, 89 (29%) were classified as new\u2010HiR. Patients with new\u2010HiR NDMM had substantially worse progression\u2010free survival (PFS) (hazard ratio [HR] 4.17, 95% confidence interval [CI] 2.58\u20136.73;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and overall survival (OS) (HR 5.13, 95% CI 2.44\u201310.80,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). The new IMS\/IMWG criteria better fit a predictive model for PFS and OS than the old criteria. The new criteria were able to identify misclassified patients under the old criteria. The 2025 IMWG\/IMS criteria outperform legacy risk classification systems in the identification of patients at high risk for early progression and death despite modern therapy.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70359","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T07:23:47Z","timestamp":1771226627000},"page":"1001-1008","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Validation of the 2025\n                    <scp>IMS<\/scp>\n                    \/\n                    <scp>IMWG<\/scp>\n                    risk classification in patients with newly diagnosed multiple myeloma treated with quadruplets and autologous stem cell transplant"],"prefix":"10.1111","volume":"208","author":[{"given":"Priyanka","family":"Venkatesh","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine University of Alabama at Birmingham School of Medicine  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0467-1819","authenticated-orcid":false,"given":"Gayathri","family":"Ravi","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine University of Alabama at Birmingham School of Medicine  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4377-9742","authenticated-orcid":false,"given":"Binod","family":"Dhakal","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6975-1086","authenticated-orcid":false,"given":"Natalie S.","family":"Callander","sequence":"additional","affiliation":[{"name":"Division of Hematology, Medical Oncology and Palliative Care, Department of Medicine University of Wisconsin  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Medvedova","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Medical Oncology, Knight Cancer Institute Oregon Health and Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhagirathbhai R.","family":"Dholaria","sequence":"additional","affiliation":[{"name":"Division of Hematology Oncology, Department of Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smith","family":"Giri","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine University of Alabama at Birmingham School of Medicine  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly N.","family":"Godby","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine University of Alabama at Birmingham School of Medicine  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca W.","family":"Silbermann","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Medical Oncology, Knight Cancer Institute Oregon Health and Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fady M.","family":"Mikhail","sequence":"additional","affiliation":[{"name":"Department of Genetics University of Alabama at Birmingham School of Medicine  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Forest","family":"Huls","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Alabama at Birmingham School of Medicine  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5474-3289","authenticated-orcid":false,"given":"Vishnu","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Alabama at Birmingham School of Medicine  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano J.","family":"Costa","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine University of Alabama at Birmingham School of Medicine  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Bal","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine University of Alabama at Birmingham School of Medicine  Birmingham Alabama 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