{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:00:11Z","timestamp":1792166411727,"version":"4.4.0"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Stroke in sickle cell disease (SCD) has been well characterized in children, but data in adults remain insufficient, particularly regarding long\u2010term functional consequences. The objective was to determine lifetime prevalence of symptomatic stroke, followed by characterization of stroke type, aetiology, treatments and functional status at last follow\u2010up. We retrospectively reviewed adults (\u226518\u2009years) with any SCD phenotype followed at a tertiary centre from 2011 to 2023. Functional status was assessed using the Montreal Cognitive Assessment (MoCA) and Modified Rankin Scale (mRS). Among 454 adults with all major phenotypes of SCD, median age was 32\u2009years [range 18\u201379] and 261 (57.5%) were women. At last follow\u2010up, 21 individuals (4.6%) had a confirmed history of symptomatic stroke (median age at stroke onset of 42\u2009years [range 4\u201368]), including 14 (3.1%) with cerebral infarction (median age 32\u2009years [4\u201368]) and 7 (1.5%) with intracranial haemorrhage (median age 45\u2009years [20\u201365]). Stroke was associated with marked long\u2010term impairment, represented by lower MoCA (20.6 (\u00b11.3) vs. 26.1 (\u00b10.2),\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and higher mRS (2 [1\u20133] vs. 0 [0\u20131],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). These findings fill a critical evidence gap and underscore the urgency of targeted prevention and intervention strategies in this high\u2010risk population.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70362","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T08:30:50Z","timestamp":1770798650000},"page":"1063-1073","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Stroke burden and functional impacts in adults with sickle cell disease"],"prefix":"10.1111","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0406-8211","authenticated-orcid":false,"given":"Jonathan","family":"St\u2010Onge","sequence":"first","affiliation":[{"name":"Division of Hematology\u2010Oncology Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM)  Montreal Quebec Canada"},{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzvetena","family":"Hristova","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrystelle","family":"Charles","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olena","family":"Bereznyakova","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"},{"name":"Division of Neurology Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM)  Montreal Quebec Canada"},{"name":"CHUM Research Center (CRCHUM)  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Jacquin","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"},{"name":"Division of Neurology Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM)  Montreal Quebec Canada"},{"name":"CHUM Research Center (CRCHUM)  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Pouliot","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM)  Montreal Quebec Canada"},{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janick","family":"Caron\u2010Lecuyer","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM)  Montreal Quebec Canada"},{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia","family":"Stevanovik","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara\u2010Maude","family":"Desforges","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM)  Montreal Quebec Canada"},{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costa M.","family":"Kazadi","sequence":"additional","affiliation":[{"name":"CHUM Research Center (CRCHUM)  Montreal Quebec 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Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Fort\u00e9","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM)  Montreal Quebec Canada"},{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"},{"name":"CHUM Research Center (CRCHUM)  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"issue":"1","key":"e_1_2_12_2_1","first-page":"288","article-title":"Cerebrovascular accidents in sickle cell disease: rates and risk factors","volume":"91","author":"Ohene\u2010Frempong 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KazadiC et\u00a0al.Lifetime prevalence of stroke within an adult population with sickle cell disease: a cross\u2010sectional study.2024.66th American Society of Hematology Annual Meeting & Exposition San Diego."}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70362","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.70362","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70362","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T05:43:22Z","timestamp":1782107002000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.70362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,11]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/bjh.70362"],"URL":"https:\/\/doi.org\/10.1111\/bjh.70362","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,11]]},"assertion":[{"value":"2025-09-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}