{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:46:22Z","timestamp":1792518382522,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Allogeneic haematopoietic cell transplantation (alloHCT) remains a potentially curative strategy for relapsed or refractory lymphoid malignancies, even in the post\u2010chimeric antigen receptor T\u2010cell and bispecific antibody era. While reduced\u2010intensity conditioning regimens offer lower non\u2010relapse mortality (NRM), relapse rates remain high, and optimal conditioning strategies in the setting of post\u2010transplant cyclophosphamide (PTCy) prophylaxis remain undefined. In this retrospective, international multicentre study, the primary end\u2010point was NRM. We compared treosulfan\/fludarabine (Treo\/Flu) versus thiotepa\/busulfan\/fludarabine (TBF) in 178 adults with lymphoid malignancies undergoing first alloHCT with PTCy and peripheral blood grafts. Three\u2010year NRM was 14.0% with Treo\/Flu versus 33.0% with TBF. On multivariate analysis, Treo\/Flu was associated with significantly lower 3\u2010year NRM (hazard ratio [HR] 0.44; 95% confidence interval [CI], 0.22\u20130.87;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.018). Conditioning regimen was not independently associated with overall survival (OS) or progression\u2010free survival (PFS), and relapse incidence was similar between regimens. Moderate to severe chronic graft\u2010versus\u2010host disease (GVHD) was higher with Treo\/Flu (26.0% vs. 9.9%; HR 2.43; 95% CI, 1.09\u20135.43;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03), while GVHD\u2010free\/relapse\u2010free survival (GFRS) was comparable. Findings were consistent in a prespecified propensity score\u2010matched sensitivity analysis. These findings support Treo\/Flu as a potentially safer reduced\u2010toxicity conditioning option than TBF in the context of PTCy\u2010based GVHD prophylaxis for lymphoid malignancies and warrant prospective validation.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70367","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T11:12:46Z","timestamp":1770894766000},"page":"1017-1026","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Treosulfan\/fludarabine versus thiotepa\/busulfan\/fludarabine for allogeneic haematopoietic cell transplantation in lymphoma in the post\u2010transplant cyclophosphamide era: A\n                    <scp>GETH<\/scp>\n                    \u2010\n                    <scp>TC<\/scp>\n                    study"],"prefix":"10.1111","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6601-7276","authenticated-orcid":false,"given":"Marta","family":"Pe\u00f1a","sequence":"first","affiliation":[{"name":"Clinical Hematology Department Institut Catal\u00e0 d'Oncologia\u2010Hospitalet, IDIBELL  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0844-0708","authenticated-orcid":false,"given":"Lorenzo","family":"Lazzari","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplantation Unit IRCCS San Raffaele Scientific Institute  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego F.","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Clinical Hematology Department Institut Catal\u00e0 d'Oncologia\u2010Hospitalet, IDIBELL  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0873-0123","authenticated-orcid":false,"given":"Fabio","family":"Ciceri","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplantation Unit IRCCS San Raffaele Scientific Institute  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aitana","family":"Balaguer\u2010Rosell\u00f3","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Universitari i Polit\u00e8cnic La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Sanz","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Universitari i Polit\u00e8cnic La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria J.","family":"Pascual","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Regional Universitario de M\u00e1laga  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4015-0831","authenticated-orcid":false,"given":"Ana","family":"Benzaqu\u00e9n","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Cl\u00ednico Universitario de Valencia\u2010INCLIVA  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L.","family":"Pi\u00f1ana","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Cl\u00ednico Universitario de Valencia\u2010INCLIVA  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Q.","family":"Salas","sequence":"additional","affiliation":[{"name":"Hematopoietic Cell Transplantation Unit Hospital Cl\u00ednic de Barcelona, ICHMO  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agustin","family":"Nieto\u2010Vazquez","sequence":"additional","affiliation":[{"name":"Hematology Department Complexo Hospitalario de Vigo \u2010 Hospital \u00c1lvaro Cunqueiro  Vigo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Espa\u00f1ol","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Cl\u00ednico Universitario Virgen de la Arrixaca  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Huguet","sequence":"additional","affiliation":[{"name":"Hematology Department, Institut Catal\u00e0 d'Oncologia\u2010Badalona, Hospital Germans Trias i Pujol  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyre","family":"Bento","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Universitario Son Espases, IdISBa  Palma De Mallorca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo J.","family":"Saez","sequence":"additional","affiliation":[{"name":"Hematology Department Hospital Universitario 12 de Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pere","family":"Barba","sequence":"additional","affiliation":[{"name":"Hematology Department University Hospital Vall d'Hebron  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Filaferro","sequence":"additional","affiliation":[{"name":"Grupo Espa\u00f1ol de Trasplante de Progenitores Hematopoy\u00e9ticos y Terapia Celular (GETH\u2010TC), Data Office  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan A.","family":"Carbonell Asins","sequence":"additional","affiliation":[{"name":"Biostatistics Unit. 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