{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T13:09:11Z","timestamp":1778936951880,"version":"3.51.4"},"reference-count":63,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["NIHR203334"],"award-info":[{"award-number":["NIHR203334"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Blood transfusion is one of the most common interventions in hospitals. Blood tests that support this widespread practice are considered routine, such as \u2018group and save\u2019 (also known as \u2018type and screen\u2019), yet there has been very limited evaluation of the needs for these tests and the associated costs. The aim of this systematic review is to synthesise international evidence on the costs of group and save and crossmatch tests and their component processes. Seventy\u2010two studies published between 2012 and 2023 were identified and data were extracted. Most cost estimates were derived from local institutional sources with few using national reference data, and reporting methods varied widely. Median unit costs for group and save tests were \u00a319.8 (interquartile range [IQR] \u00a311.8\u2013\u00a352.5) overall, \u00a313.8 in the United Kingdom and \u00a357.4 in the United States. Crossmatch costs were \u00a39.6 (IQR \u00a35.9\u2013\u00a337.3). Understanding costs for group and save testing will inform hospital teams making decisions about sample requirements for procedures with a low likelihood of transfusion. It also provides benchmarking to assess the impact of implementing electronic systems to improve safety and efficiency of transfusion practice.<\/jats:p>","DOI":"10.1111\/bjh.70370","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:20:08Z","timestamp":1773001208000},"page":"1196-1206","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Substantial international variation in the cost of blood group and save and crossmatch: A systematic review"],"prefix":"10.1111","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9922-4810","authenticated-orcid":false,"given":"Gianluca","family":"Fabiano","sequence":"first","affiliation":[{"name":"Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Pinedo\u2010Villanueva","sequence":"additional","affiliation":[{"name":"Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shona","family":"Kirtley","sequence":"additional","affiliation":[{"name":"Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Centre for Statistics in Medicine University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Cole","sequence":"additional","affiliation":[{"name":"Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artin","family":"Manafi\u2010Khosroshahi","sequence":"additional","affiliation":[{"name":"School of Medicine and Biomedical Sciences University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bilal","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Medical Sciences Division University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Singleton","sequence":"additional","affiliation":[{"name":"School of Medicine and Biomedical Sciences University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biruk","family":"Tsegaye","sequence":"additional","affiliation":[{"name":"Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Centre for Statistics in Medicine University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei Shao","family":"Tung","sequence":"additional","affiliation":[{"name":"The Medical School The University of Sheffield  Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2220-5210","authenticated-orcid":false,"given":"Florian","family":"Tomini","sequence":"additional","affiliation":[{"name":"Wolfson Institute of Population Health Queen Mary University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayley G.","family":"Evans","sequence":"additional","affiliation":[{"name":"NIHR Blood and Transplant Research Unit in Data\u2010Driven Transfusion Practice, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2375-7503","authenticated-orcid":false,"given":"Mike F.","family":"Murphy","sequence":"additional","affiliation":[{"name":"NIHR Blood and Transplant Research Unit in Data\u2010Driven Transfusion Practice, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine University of Oxford  Oxford UK"},{"name":"NHS Blood and Transplant Oxford University Hospitals NHS Foundation Trust and University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7414-4950","authenticated-orcid":false,"given":"Simon J.","family":"Stanworth","sequence":"additional","affiliation":[{"name":"NIHR Blood and Transplant Research Unit in Data\u2010Driven Transfusion Practice, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine University of Oxford  Oxford UK"},{"name":"NHS Blood and Transplant Oxford University Hospitals NHS Foundation Trust and University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Dhiman","sequence":"additional","affiliation":[{"name":"Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Centre for Statistics in Medicine University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antony J. 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