{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T05:49:41Z","timestamp":1782107381191,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100012016","name":"Institut National de Sant\u00e9 Publique du Qu\u00e9bec","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012016","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Few studies have compared the prevalence of transfusion reactions (TRs) in paediatric and adult recipients, and none have been conducted in Canada. We carried out a retrospective cross\u2010sectional study of TRs reported in a Canadian haemovigilance system (i.e. Qu\u00e9bec's haemovigilance system [QHS]) from 1 January 2005 to 31 December 2022. QHS is a province\u2010wide voluntary haemovigilance system that records TRs among blood recipients. Overall, 5\u2009372\u2009752 transfusions were recorded; 23\u2009946 reactions deemed definitely, probably or possibly associated with transfusion were analysed (paediatric recipients\u2009=\u20091951 [8.2%]; adults\u2009=\u200921\u2009995 [91.9%]). Paediatric recipients experienced higher rates (95% confidence interval) of reported TRs than adults (97.05 [92.79\u2013101.45] vs. 42.53 [41.97\u201343.10] per 10\u2009000 transfusions). This difference was predominantly driven by children (age: \u226512\u2009months to &lt;18\u2009years), platelets, red blood cells and minor allergic reactions (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). Similar results were obtained for nearly all individual TRs except transfusion\u2010associated circulatory overload, whose rates were lower among paediatric recipients (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). However, paediatric age subgroups exhibited divergent patterns: recipients aged &lt;1\u2009month had lower rates than adults, while those aged \u22651 to &lt;12\u2009months and \u226512\u2009months to &lt;18\u2009years had higher rates (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). The aforementioned differences were consistently observed throughout the 18\u2010year period, with only minor year\u2010to\u2010year variations in subgroups and for individual TRs. We conclude that paediatric recipients consistently exhibited higher rates of reported TRs than adult recipients.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70371","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T11:39:33Z","timestamp":1771414773000},"page":"1074-1083","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transfusion reactions reported to the Qu\u00e9bec haemovigilance system between 2005 and 2022: A comparison of paediatric and adult recipients"],"prefix":"10.1111","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0450-1818","authenticated-orcid":false,"given":"Nancy","family":"Robitaille","sequence":"first","affiliation":[{"name":"Transfusion Medicine H\u00e9ma\u2010Qu\u00e9bec  Montr\u00e9al Quebec Canada"},{"name":"Division of Haematology\u2010Oncology, Department of Paediatrics Centre Hospitalier Universitaire Sainte\u2010Justine  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0832-0792","authenticated-orcid":false,"given":"Samuel","family":"Rochette","sequence":"additional","affiliation":[{"name":"Medical Affairs and Innovation H\u00e9ma\u2010Qu\u00e9bec  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl Itaj","family":"Nawej","sequence":"additional","affiliation":[{"name":"Direction des risques biologiques Institut National de Sant\u00e9 Publique du Qu\u00e9bec  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1748-4198","authenticated-orcid":false,"given":"Antoine","family":"Lewin","sequence":"additional","affiliation":[{"name":"Medical Affairs and Innovation H\u00e9ma\u2010Qu\u00e9bec  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Lambert","sequence":"additional","affiliation":[{"name":"Direction des risques biologiques Institut National de Sant\u00e9 Publique du Qu\u00e9bec  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14233"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12313"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12373"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12827"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14504"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00995.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.660297"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-020-00869-6"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000365"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2021.103152"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12520"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12677"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2012.12.009"},{"issue":"4","key":"e_1_2_11_15_1","first-page":"702","article-title":"Transfusion\u2010related acute lung injury in a paediatric intensive care unit of Pakistan","volume":"29","author":"Tariq M","year":"2017","journal-title":"J Ayub Med Coll Abbottabad JAMC"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12833"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07022.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14359"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.18074"},{"issue":"5","key":"e_1_2_11_20_1","first-page":"428","article-title":"Dissecting the complexity of pediatric blood transfusions and risk of adverse reactions in Aotearoa New Zealand","volume":"21","author":"Wei WH","year":"2023","journal-title":"Blood Transfus"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01484.x"},{"key":"e_1_2_11_22_1","unstructured":"World Health Organization.A guide to establishing a national haemovigilance system [Internet]. [cited 2022 June 1]. Available from:https:\/\/www.who.int\/publications\/i\/item\/9789241549844"},{"key":"e_1_2_11_23_1","unstructured":"Institut National de Sant\u00e9 Publique du Qu\u00e9bec.Guide de d\u00e9claration des \u00e9v\u00e9nements ind\u00e9sirables associ\u00e9s \u00e0 la transfusion de produits sanguins [Internet]. [cited 2022 June 1]. Available from:https:\/\/www.inspq.qc.ca\/publications\/2313"},{"key":"e_1_2_11_24_1","unstructured":"International Society of Blood Transfusion.Adverse effects of transfusion [Internet]. [cited 2025 Aug 11]. Available from:https:\/\/www.isbtweb.org\/resources\/educational\u2010modules\u2010on\u2010clinical\u2010use\u2010of\u2010blood\/adverse\u2010effects\u2010of\u2010transfusion.html"},{"key":"e_1_2_11_25_1","volume-title":"CAN\/CSA\u2010Z902:25 \u2010 National Standard of Canada \u2010 blood and blood components","author":"Canadian Standards Association","year":"2025"},{"key":"e_1_2_11_26_1","first-page":"899","volume-title":"Technical manual","author":"Cohn CS","year":"2023"},{"issue":"4","key":"e_1_2_11_27_1","first-page":"S19","article-title":"Supplemental findings of the 2021 National Blood Collection and Utilization Survey","volume":"63","author":"Kracalik I","year":"2023","journal-title":"Transfusion"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15138"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14509"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12758"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70371","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.70371","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T05:43:02Z","timestamp":1782106982000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.70371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,18]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/bjh.70371"],"URL":"https:\/\/doi.org\/10.1111\/bjh.70371","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,18]]},"assertion":[{"value":"2025-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}