{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:41Z","timestamp":1787013941090,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceutica","doi-asserted-by":"publisher","award":["54767414MMY2042"],"award-info":[{"award-number":["54767414MMY2042"]}],"id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The progression pattern of multiple myeloma is heterogeneous and often characterised by asymptomatic biochemical progression preceding the onset of organ\u2010related symptoms. It is unknown whether pre\u2010emptive treatment of biochemical progression can affect long\u2010term outcomes. The PREDATOR\u2010BR trial is a randomised, multicentre study that enrolled 92 patients who met criteria for biochemical progression but not the criteria for significant paraprotein relapse (SPR). The participants were assigned to either daratumumab monotherapy or observation. The primary end\u2010point was event\u2010free survival (EFS), defined as the time until clinical relapse, SPR or death from any cause. At the prespecified interim analysis with a median follow\u2010up time of 16.7\u2009months, the median EFS was 28.9\u2009months with daratumumab and 4.0\u2009months in the observation arm (hazard ratio [HR], 0.25; 95% confidence interval [CI], 0.14\u20130.43). The response rate was 61.0% in the treatment arm and 6.8% in the observation arm (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). The 24\u2010month overall survival was 100% in the treatment group and 70.5% in the observation group (HR, 0.04; 95% CI, 0.00\u20130.34). Treatment was associated with manageable safety and no deterioration in quality of life. These results suggest that early treatment initiation during asymptomatic biochemical relapse of multiple myeloma may delay clinical relapse and prolong patient survival.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70373","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T07:22:34Z","timestamp":1771399354000},"page":"1314-1323","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Daratumumab or active observation for asymptomatic biochemical relapse in patients with multiple myeloma"],"prefix":"10.1111","volume":"208","author":[{"given":"Krzysztof","family":"Jamroziak","sequence":"first","affiliation":[{"name":"Department of Haematology, Transplantation and Internal Medicine Medical University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Dytfeld","sequence":"additional","affiliation":[{"name":"Department of Haematology and Bone Marrow Transplantation Pozna\u0144 University of Medical Sciences  Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadeusz","family":"Kubicki","sequence":"additional","affiliation":[{"name":"Department of Haematology and Bone Marrow Transplantation Pozna\u0144 University of Medical Sciences  Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Dutka","sequence":"additional","affiliation":[{"name":"Department of Haematology and Transplantology Medical University of Gda\u0144sk  Gda\u0144sk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Wr\u00f3bel","sequence":"additional","affiliation":[{"name":"Department and Clinic of Haematology, Cellular Therapies and Internal Medicine Wroc\u0142aw Medical University  Wroc\u0142aw 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