{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T18:07:24Z","timestamp":1793902044278,"version":"4.8.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Allogeneic haematopoietic stem cell transplantation (allo\u2010HSCT) is potentially curative for high\u2010risk haematological diseases but may lead to persistent cytopenias such as poor graft function (PGF) or graft failure (GF). Thrombopoietin receptor agonists (TPO\u2010RAs) like eltrombopag or romiplostim are effective but have pharmacologic and practical limitations. This retrospective study evaluated avatrombopag, a novel oral TPO\u2010RA, in 11 adult patients with persistent thrombocytopenia following allo\u2010HSCT (8 with PGF and 3 with GF). Avatrombopag was initiated at 20\u2009mg\/day orally, escalated to 40\u2009mg\/day after a median of 21\u2009days and up to 60\u2009mg\/day after a median of 36\u2009days as the maximum dose in patients who did not achieve an adequate response. The median time to response was 55\u2009days, with a median treatment duration of 134\u2009days. A haematological response was achieved in all eight patients with PGF, with significant improvements in platelet counts and other haematopoietic lineages. In contrast, no response was documented in patients with GF. No severe adverse events or complications were reported. Notably, these findings suggest that avatrombopag is a promising alternative for PGF, offering practical advantages over other TPO\u2010RAs, although prospective studies are needed with a larger sample size of patients to confirm these results.<\/jats:p>","DOI":"10.1111\/bjh.70378","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T05:45:01Z","timestamp":1771652701000},"page":"1027-1035","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Avatrombopag for post\u2010transplant thrombocytopenia following allogeneic haematopoietic stem cell transplantation: A single\u2010centre retrospective study"],"prefix":"10.1111","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9459-0827","authenticated-orcid":false,"given":"Cristian","family":"Alberdi\u2010Lema","sequence":"first","affiliation":[{"name":"Pharmacy Service, Division of Medicines Hospital Cl\u00ednic Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Garc\u00eda\u2010Villaronga","sequence":"additional","affiliation":[{"name":"Pharmacy Service, Division of Medicines Hospital Cl\u00ednic Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2699-214X","authenticated-orcid":false,"given":"Thais","family":"Linzodo\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Pharmacy Service, Division of Medicines Hospital Cl\u00ednic Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Carcelero","sequence":"additional","affiliation":[{"name":"Pharmacy Service, Division of Medicines Hospital Cl\u00ednic Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela","family":"Riu","sequence":"additional","affiliation":[{"name":"Pharmacy Service, Division of Medicines Hospital Cl\u00ednic Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e9s","family":"Monge\u2010Escart\u00edn","sequence":"additional","affiliation":[{"name":"Pharmacy Service, Division of Medicines Hospital Cl\u00ednic Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Su\u00e1rez\u2010Lled\u00f3","sequence":"additional","affiliation":[{"name":"Hematopoietic Transplantation Unit and Hematology Department Clinical Institute of Hematology and Oncology (ICAMS), Hospital Cl\u00ednic Barcelona  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Hematology Department, Faculty of Medicine and Health Sciences University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laia","family":"Guardia","sequence":"additional","affiliation":[{"name":"Hematopoietic Transplantation Unit and Hematology Department Clinical Institute of Hematology and Oncology (ICAMS), Hospital Cl\u00ednic Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Pedraza","sequence":"additional","affiliation":[{"name":"Blood and Tissue Bank, Hospital Cl\u00ednic Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0370-3436","authenticated-orcid":false,"given":"Cristina","family":"Sanz","sequence":"additional","affiliation":[{"name":"Blood and Tissue Bank, Hospital Cl\u00ednic Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Charry","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Hematology Department, Faculty of Medicine and Health Sciences University of Barcelona  Barcelona Spain"},{"name":"Apheresis &amp; Cellular Therapy Unit, Department of Hemotherapy and Hemostasis ICAMS, Hospital Cl\u00ednic Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Cid","sequence":"additional","affiliation":[{"name":"Hematopoietic Transplantation Unit and Hematology Department Clinical Institute of Hematology and Oncology (ICAMS), Hospital Cl\u00ednic Barcelona  Barcelona Spain"},{"name":"Apheresis &amp; Cellular Therapy Unit, Department of Hemotherapy and Hemostasis ICAMS, Hospital Cl\u00ednic Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2593-833X","authenticated-orcid":false,"given":"Miquel","family":"Lozano","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Hematology Department, Faculty of Medicine and Health Sciences University of Barcelona  Barcelona Spain"},{"name":"Apheresis &amp; Cellular Therapy Unit, Department of Hemotherapy and Hemostasis ICAMS, Hospital Cl\u00ednic Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enric","family":"Carreras","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3 i Institut de Recerca Josep Carreras contra la leuc\u00e8mia (Campus Cl\u00ednic)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Rosi\u00f1ol","sequence":"additional","affiliation":[{"name":"Hematopoietic Transplantation Unit and Hematology Department Clinical Institute of Hematology and Oncology (ICAMS), Hospital Cl\u00ednic Barcelona  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Hematology Department, Faculty of Medicine and Health Sciences University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8401-7306","authenticated-orcid":false,"given":"Carmen","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Hematopoietic Transplantation Unit and Hematology Department Clinical Institute of Hematology and Oncology (ICAMS), Hospital Cl\u00ednic Barcelona  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Hematology Department, Faculty of Medicine and Health Sciences University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Fern\u00e1ndez\u2010Avil\u00e9s","sequence":"additional","affiliation":[{"name":"Hematopoietic Transplantation Unit and Hematology Department Clinical Institute of Hematology and Oncology (ICAMS), Hospital Cl\u00ednic Barcelona  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Hematology Department, Faculty of Medicine and Health Sciences University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Rovira","sequence":"additional","affiliation":[{"name":"Hematopoietic Transplantation Unit and Hematology Department Clinical Institute of Hematology and Oncology (ICAMS), Hospital Cl\u00ednic Barcelona  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Hematology Department, Faculty of Medicine and Health Sciences University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda\u2010Queralt","family":"Salas","sequence":"additional","affiliation":[{"name":"Hematopoietic Transplantation Unit and Hematology Department Clinical Institute of Hematology and Oncology (ICAMS), Hospital Cl\u00ednic Barcelona  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Hematology Department, Faculty of Medicine and Health Sciences University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-022-01691-w"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2018.11.001"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-025-02524-2"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-024-02251-0"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021004537"},{"issue":"1","key":"e_1_2_10_7_1","first-page":"23","article-title":"Post\u2010transplant complications","volume":"6","author":"Halahleh K","year":"2023","journal-title":"Blood Cells 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