{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T13:08:21Z","timestamp":1778936901331,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010318","name":"Landelijke Stichting voor Blinden en Slechtzienden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010318","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010372","name":"Rotterdamse Stichting Blindenbelangen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010372","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Sickle cell disease (SCD), encompassing genotypes such as HbSS and HbSC,\u00a0leads to retinal complications such as sickle cell retinopathy (SCR) and maculopathy (SCM) through poorly understood mechanisms. This study explored associations of a panel of circulating angiogenesis\u2010related factors with SCR and SCM. Adult HbSS (homozygous SCD;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200933) and HbSC (compound heterozygous SCD;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200933) patients underwent ophthalmic examination, including optical coherence tomography angiography, to assess SCR stage and presence of SCM. Plasma levels of circulating angiogenesis\u2010related factors were analysed, with selected markers (angiopoietin\u20102, vascular endothelial growth factor [VEGF], granulocyte colony\u2010stimulating factor, endoglin, endostatin, interleukin [IL]\u20106 and IL\u201010) assessed using enzyme\u2010linked immunosorbent assay. Proliferative SCR (PSCR) was present in 5 (15.2%) HbSS and 21 (63.6%) HbSC patients. Foveal avascular zone abnormalities and macular thinning were present in 50.8% and 48.4% of patients respectively. Most vascular factors, including VEGF, showed no association with SCR or SCM. However, angiopoietin\u20102 was higher in HbSS patients, independent of SCR stage or SCM, and correlated with IL\u20106, IL\u201010, VEGF, reticulocyte counts, and lactate dehydrogenase (LDH). In HbSC patients, endostatin levels were highest in those with PSCR (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.030). While most proteins were unrelated to retinal outcomes, angiopoietin\u20102 elevation may reflect HbSS\u2010specific systemic hypoxia. Elevated endostatin in HbSC patients with PSCR suggests a potential role in PSCR development. These findings offer new leads for understanding SCD\u2010related retinal disease.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70385","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T07:29:14Z","timestamp":1771572554000},"page":"1398-1406","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Circulating angiogenesis\u2010related biomarkers in sickle cell retinopathy and maculopathy"],"prefix":"10.1111","volume":"208","author":[{"given":"Rajani P.","family":"Brandsen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Amsterdam UMC  Amsterdam the Netherlands"},{"name":"Department of Haematology Amsterdam UMC  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingeborg","family":"Klaassen","sequence":"additional","affiliation":[{"name":"Ocular Angiogenesis Group, Department of Ophthalmology Amsterdam UMC  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9e","family":"de Caluwe","sequence":"additional","affiliation":[{"name":"Ocular Angiogenesis Group, Department of Ophthalmology Amsterdam UMC  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erfan","family":"Nur","sequence":"additional","affiliation":[{"name":"Department of Haematology Amsterdam UMC  Amsterdam the Netherlands"},{"name":"Sanquin Research and Landsteiner Laboratory Department of Blood Cell Research  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart J.","family":"Biemond","sequence":"additional","affiliation":[{"name":"Department of Haematology Amsterdam UMC  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roselie M. H.","family":"Diederen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Amsterdam UMC  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinier O.","family":"Schlingemann","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Amsterdam UMC  Amsterdam the Netherlands"},{"name":"Ocular Angiogenesis Group, Department of Ophthalmology Amsterdam UMC  Amsterdam the Netherlands"},{"name":"Department of Ophthalmology University of Lausanne, Jules\u2010Gonin Eye Hospital, Fondation Asile des Aveugles  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-189012"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022009147"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.14369"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000004247"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2017.3008"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-019-04294-2"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001486"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183320"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.83.7.838"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713689409042407"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4835(03)00174-X"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2004.058164"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2014.08.003"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(71)90429-6"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.5.1555"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V74.4.1403.1403"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2006.01.011"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000012095"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06103.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2015.09.007"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.119727"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(02)00043-5"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-1951"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019873"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.00627.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-12-061697"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000002057"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70385","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.70385","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70385","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T12:30:51Z","timestamp":1778934651000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.70385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,19]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/bjh.70385"],"URL":"https:\/\/doi.org\/10.1111\/bjh.70385","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,19]]},"assertion":[{"value":"2025-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}