{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T10:55:58Z","timestamp":1781520958966,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Older patients with classic Hodgkin lymphoma experience poorer outcomes than younger individuals, due to comorbidities and functional limitations affecting treatment tolerance. In this retrospective single\u2010centre study of 140 patients, we evaluated treatment patterns, outcomes and the prognostic value of two geriatric scores: the Age, Comorbidities and Albumin (ACA) Index and the Frailty Score. Most patients (87.9%) received standard ABVD (doxorubicin, bleomycin, vinblastine and dacarbazine)\/AVD (doxorubicin, vinblastine and dacarbazine) regimens. At median follow\u2010up (65\u2009months), 5\u2010year progression\u2010free survival (PFS) and overall survival (OS) were 65% and 78.5%, respectively; treatment\u2010related mortality was 7.8%. First\u2010line therapy (AVD\u2010based versus other) significantly influenced PFS (61.8% vs. 23.5%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002) and OS (69.1% vs. 35.3%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001). ACA Index stratified patients into four risk categories with progressively lower 5\u2010year OS (92%\u201364.3%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.003). According to Frailty Score, 37.9% were fit, 54.3% unfit and 7.8% frail, with corresponding 5\u2010year OS of 79.2%, 59.2% and 36.4% (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). Multivariate analysis identified age \u226580\u2009years, extra\u2010nodal involvement and advanced stage according to German Hodgkin Study Group (GHSG) classification as independent predictors of PFS; age \u226580\u2009years, advanced stage (GHSG) and Frailty Score independently predicted OS. Our findings confirm that standard therapies achieve favourable outcomes in older patients, but chronological age alone is insufficient for treatment decisions. The Frailty Score offers an accessible prognostic tool to guide therapy, supporting the integration of geriatric assessment into treatment planning for this underrepresented population.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70390","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T05:49:46Z","timestamp":1771652986000},"page":"1296-1305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic impact of treatment\u2010related and geriatric factors in older patients with classic Hodgkin lymphoma: A real\u2010life cohort study"],"prefix":"10.1111","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2803-3766","authenticated-orcid":false,"given":"Silvio","family":"Ligia","sequence":"first","affiliation":[{"name":"Hematology, Department of Translational and Precision Medicine Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6190-9635","authenticated-orcid":false,"given":"Giovanni Manfredi","family":"Assanto","sequence":"additional","affiliation":[{"name":"Hematology, Department of Translational and Precision Medicine Sapienza University of Rome  Rome Italy"},{"name":"Hematology AOU Policlinico Umberto I  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Soriano","sequence":"additional","affiliation":[{"name":"Hematology, Department of Translational and Precision Medicine Sapienza University of Rome  Rome Italy"},{"name":"Hematology AOU Policlinico Umberto I  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8090-3880","authenticated-orcid":false,"given":"Luca Vincenzo","family":"Cappelli","sequence":"additional","affiliation":[{"name":"Hematology, Department of Translational and Precision Medicine Sapienza University of Rome  Rome Italy"},{"name":"Hematology AOU Policlinico Umberto I  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1872-2218","authenticated-orcid":false,"given":"Mauro","family":"Passucci","sequence":"additional","affiliation":[{"name":"Hematology, Department of Translational and Precision Medicine Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Annechini","sequence":"additional","affiliation":[{"name":"Hematology AOU Policlinico Umberto I  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianna Maria","family":"D'Elia","sequence":"additional","affiliation":[{"name":"Hematology AOU Policlinico Umberto I  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7429-8004","authenticated-orcid":false,"given":"Alessandro","family":"Pulsoni","sequence":"additional","affiliation":[{"name":"Hematology, Department of Translational and Precision Medicine Sapienza University of Rome  Rome Italy"},{"name":"Hematology Unit S. Maria Goretti Hospital  Latina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Martelli","sequence":"additional","affiliation":[{"name":"Hematology, Department of Translational and Precision Medicine Sapienza University of Rome  Rome Italy"},{"name":"Hematology AOU Policlinico Umberto I  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6864-9533","authenticated-orcid":false,"given":"Ilaria","family":"Del Giudice","sequence":"additional","affiliation":[{"name":"Hematology, Department of Translational and Precision Medicine Sapienza University of Rome  Rome Italy"},{"name":"Hematology AOU Policlinico Umberto I  Rome 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